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Your search keyword '"Srinivas M. Tipparaju"' showing total 7 results
Start Over Author "Srinivas M. Tipparaju" Journal the faseb journal
7 results on '"Srinivas M. Tipparaju"'

6. Mutation of Kvβ2 active site attenuates cardiac injury: role of repolarization reserve (864.2)

Author

Siva K. Panguluri, Srinivas M. Tipparaju, Kalyan C. Chapalamadugu, and Jared Tur

Subjects
medicine.medical_specialty, Mutation, Chemistry, medicine.medical_treatment, Mutant, Wild type, Gating, medicine.disease_cause, Biochemistry, Potassium channel, Endocrinology, Internal medicine, Anesthesia, Genetics, medicine, Repolarization, Molecular Biology, Saline, Ex vivo, Biotechnology
Abstract

Cardiac Kvβ2 subunit alters gating and expression of potassium channels. However, the physiological significance remains unknown. Therefore, we evaluated the role of Kvβ2 in cardiac injury. We used 14 week male wild type (Wt) or mutant Kvβ2:PM (active site mutant; Y90F) mice, infused with saline or isoproterenol (Iso, 30mg/kg; bw/day) for 14 days. Iso treatment resulted in cardiac hypertrophy in both mice as noted by histomorphological analysis. Echocardiographic assessment revealed significant decrease (p

Published
2014

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