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7. B vitamins reduce body weight gain and increase metabolism related enzyme activities in rats (828.11)

Author

Qiuzhen Wang, Ma Aiguo, Da Yong Wu, Hui Liang, Xiuxia Han, Yong Li, Ying Zheng, and Evert G. Schouten

Subjects
medicine.medical_specialty, Triglyceride, Chemistry, Glutathione reductase, Riboflavin, Metabolism, Biochemistry, B vitamins, chemistry.chemical_compound, Endocrinology, Internal medicine, Genetics, medicine, Thiamine, medicine.symptom, Molecular Biology, Weight gain, Niacin, Biotechnology
Abstract

B vitamins as enzyme cofactors play an important role in energy metabolism. The aim of this study was to determine whether B vitamins can affect body weight (BW) and activity of energy metabolism-related enzymes in an animal model. Fifty Wistar rats were randomly divided to 3 groups and were fed a diet containing 10% fat (LF), a diet containing 45% fat (HF), or a HF diet supplemented with B vitamins (100 mg/kg BW for both thiamine and riboflavin, 250 mg/kg niacin) (HF+B). After rats were fed for 12 weeks, HF group had significantly larger weight gain than LF group (285.2±14.8 g versus 159.1±53.0 g, P

Published
2014
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