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76 results on '"Kaushik P"'

12. Differences in Excitatory and Inhibitory Balance within the Paraventricular Nucleus Reflects Response Variability to Acute Stress

Author

Mark M. Knuepfer, Hong Zheng, Neeru M Sharma, Nicole B. Hoffman‐Schepers, and Kaushik P. Patel

Subjects
Chemistry, Inhibitory postsynaptic potential, Biochemistry, Response Variability, medicine.anatomical_structure, Genetics, Excitatory postsynaptic potential, medicine, Acute stress, Molecular Biology, Neuroscience, Nucleus, Biotechnology, Balance (ability)
Published
2018

14. Central Angiotensin II regulates Protein Inhibitor of Neuronal Nitric Oxide Synthase through post‐translational mechanisms in the Paraventricular Nucleus resulting in increased Sympathetic outflow

Author

Andrea Siqueira Haibara, Kaushik P. Patel, Kenichi Katsurada, Neeru M. Sharma, and Xuefei Liu

Subjects
Chemistry, Proteinase inhibitor, Biochemistry, Angiotensin II, Cell biology, medicine.anatomical_structure, Post translational, Genetics, medicine, Sympathetic outflow, Molecular Biology, Neuronal Nitric Oxide Synthase, Nucleus, Biotechnology
Published
2018

24. Reduced miR‐133a Results in Upregulation of Angiotensinogen in the Paraventricular Nucleus of Rats with Chronic Heart Failure

Author

Shyam Sundar Nandi, Neeru M. Sharma, Paras Kumar Mishra, Hong Zheng, and Kaushik P. Patel

Subjects
Untranslated region, medicine.medical_specialty, Chemistry, medicine.disease, Biochemistry, Endocrinology, Downregulation and upregulation, Cell culture, Hypothalamus, Neuroblastoma, Internal medicine, Glioma, Heart failure, parasitic diseases, microRNA, Genetics, medicine, Molecular Biology, hormones, hormone substitutes, and hormone antagonists, Biotechnology
Abstract

Activation of renin-angiotensin system (RAS) within the paraventricular nucleus (PVN) of the hypothalamus has been suggested to enhance sympathetic activation in chronic heart failure (CHF) condition. The contribution due to changes in angiotensinogen (AGT) per se remains to be examined. In this study, we observed a 12-fold increase in levels of AGT gene in the PVN of CHF rats compared to sham-operated controls. In order to elucidate the molecular mechanism for increased expression of AGT, we performed in silico analysis of 3'-UTR of AGT gene and found potential binding site for microRNA (miR)-133a. We found a 1.9-fold decrease in mir-133a expression in the PVN of rats with CHF. We hypothesized that decreased expression of mir-133a may be responsible for the increased expression of AGT in the PVN. To test this hypothesis we used NG108 (neuroblastoma x glioma) cell line, which endogenously expresses RAS, as our in vitro model. Overexpression of miR133a (pEZX-MR03-miR133a) in NG108 cells resulted in 1.4 and...

Published
2015

26. Angiotensin II Upregulates CAPON Expression via ERK‐MAPK‐CREB Pathway in the Paraventricular Nucleus of Rats with Chronic Heart Failure

Author

Hong Zheng, Neeru M. Sharma, Kaushik P. Patel, and Xuefei Liu

Subjects
medicine.medical_specialty, biology, Chemistry, Erk mapk, Capon, CREB, medicine.disease, Biochemistry, Angiotensin II, Endocrinology, medicine.anatomical_structure, Internal medicine, Heart failure, Genetics, medicine, biology.protein, Molecular Biology, Nucleus, Biotechnology
Published
2015

28. Renal denervation attenuates the enhanced activation of the paraventricular nucleus in heart failure: restoring nNOS! (1130.10)

Author

Hong Zheng, Kaushik P. Patel, Tamra L. Llewellyn, and Xuefei Liu

Subjects
Denervation, endocrine system, medicine.medical_specialty, business.industry, Urinary system, digestive, oral, and skin physiology, medicine.disease, Biochemistry, Excretion, Norepinephrine, Endocrinology, nervous system, Heart failure, Internal medicine, Genetics, medicine, Immunohistochemistry, business, Molecular Biology, hormones, hormone substitutes, and hormone antagonists, Immunostaining, Biotechnology, FOSB, medicine.drug
Abstract

Previously we have shown that activated paraventricular nucleus (PVN) contributes to the sympatho-excitation in chronic heart failure (HF). Afferent renal nerves project to neurons in several brain areas, including the PVN, that are involved in the regulation of the cardiovascular system. The purpose of the present study was to determine if the activation of the PVN was mediated by afferent renal nerves. Chronic HF was induced by left coronary ligation surgery for 3-4 weeks and rats were surgically renal denervated (RDN) for 2 weeks. RDN resulted in reduced levels of urinary norepinephrine excretion in rats with HF compared with sham-operated control rats. RDN resulted in reduced levels of FosB staining in the PVN in rats with HF. RDN also resulted in restoration of nNOS levels (NOS histochemistry and nNOS immunostaining) in the PVN of rats with HF. We observed that microinjections of L-NMMA (NOS inhibitor) into the PVN induced a significant smaller increase in lumbar sympathetic nerve activity in anaesth...

Published
2014

30. miR‐133a ameliorates cardiac dysfunction in diabetes: possibly by restoring β‐adrenergic receptor function and expression (1078.6)

Author

Kaushik P. Patel, Shyam Sundar Nandi, Paras Kumar Mishra, Hong Zheng, Vishalakshi Chavali, Xuefei Liu, and Neeru M. Sharma

Subjects
medicine.medical_specialty, business.industry, medicine.disease, Biochemistry, Cardiac dysfunction, Endocrinology, Fibrosis, Internal medicine, Diabetes mellitus, Cardiac hypertrophy, microRNA, cardiovascular system, Genetics, Medicine, Mir 133a, β adrenergic receptor, business, Molecular Biology, Function (biology), Biotechnology
Abstract

Inhibition of microRNA (miR)-133a causes cardiac hypertrophy and fibrosis. However, the beneficial effects of miR-133a in cardiac dysfunction remain to be examined. Furthermore, impaired contractil...

Published
2014

46. CARBONYLATION CONTRIBUTES TO SERCA2 ACTIVITY LOSS DURING DIABETES

Author

Seikoh Horiuchi, Kaushik P. Patel, Keshore R Bidasee, Chun-Hong Shao, Ryoji Nagai, and Haley L. Capek

Subjects
medicine.medical_specialty, Endocrinology, business.industry, Internal medicine, Diabetes mellitus, Genetics, medicine, medicine.disease, business, Molecular Biology, Biochemistry, Carbonylation, Biotechnology
Published
2009

47. Gene transfer of angiotensin converting enzyme 2 to the paraventricular nucleus improves attenuated nitric oxide mechanism in rats with chronic heart failure

Author

Joe‐Ann S Moser, Xuefei Liu, Kaushik P. Patel, and Hong Zheng

Subjects
Mechanism (biology), Gene transfer, Pharmacology, medicine.disease, Biochemistry, Nitric oxide, chemistry.chemical_compound, medicine.anatomical_structure, chemistry, Heart failure, Angiotensin-converting enzyme 2, Genetics, medicine, Molecular Biology, Nucleus, Biotechnology
Published
2009

49. Exercise training improves heat balance during exercise depending on tail vasodilatation mediated by modification in vascular reactivity

Author

Candido Celso Coimbra, Kaushik P. Patel, Virginia S. Lemos, Gisele Vieira Rodovalho, Juliana Bohnen Guimarães, Bruno A. Rezende, and Daniel Carvalho de Lima

Subjects
Vascular reactivity, medicine.medical_specialty, Physical medicine and rehabilitation, Heat balance, business.industry, Genetics, Medicine, Vasodilation, business, Molecular Biology, Biochemistry, Biotechnology
Published
2009

50. INCREASED CARBONYLATION OF VENTRICULAR MYOSIN HEAVY CHAINS DURING DIABETES

Author

Seikoh Horiuchi, George J. Rozanski, Frank E. Stockdale, Ryoji Nagai, Chun-Hong Shao, Kaushik P. Patel, and Keshore R. Bidasee

Subjects
Biochemistry, Chemistry, Diabetes mellitus, Myosin, Genetics, medicine, medicine.disease, Molecular Biology, Carbonylation, Biotechnology
Published
2009

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