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34 results on '"Jason X.-J. Yuan"'

2. Unique Cardio‐metabolic Consequences of Superimposed Sustained and Intermittent Hypoxia

Author

Huayi Zhao, Pritesh P. Jain, Omar A. Mesarwi, Xin Zhen, Mingmei Xiong, Esteban A. Moya, Atul Malhotra, Tatum S. Simonson, Jason X.-J. Yuan, and Mary Gautane

Subjects
medicine.medical_specialty, Cardio metabolic, business.industry, Internal medicine, Genetics, medicine, Cardiology, Intermittent hypoxia, business, Molecular Biology, Biochemistry, Biotechnology
Published
2021

5. Hypoxic Pulmonary Vasoconstriction in Isolated Mouse Lungs

Author

Ayako Makino, Susumu Hosokawa, Shamin Rahimi, Francesca Balistrieri, Jason X.-J. Yuan, Pritesh P. Jain, Mingmei Xiong, and Aleksandra Babicheva

Subjects
Pathology, medicine.medical_specialty, business.industry, Hypoxic pulmonary vasoconstriction, Genetics, Medicine, business, Molecular Biology, Biochemistry, Biotechnology
Published
2020

6. Upregulation of G protein‐couple receptor 68 (GPCR68) in pulmonary artery smooth muscle cells from animals and humans with pulmonary hypertension

Author

Pritesh P. Jain, Aleksandra Babicheva, Shamin Rahimi, Marisela Rodriguez, Jason X.-J. Yuan, and Shayan Rahimi

Subjects
medicine.medical_specialty, business.industry, G protein, medicine.disease, Biochemistry, Pulmonary hypertension, Endocrinology, Smooth muscle, Downregulation and upregulation, medicine.artery, Internal medicine, Pulmonary artery, Genetics, medicine, Receptor, business, Molecular Biology, Biotechnology
Published
2020

7. Decreased MicroRNA‐153 Promotes Endothelial‐to‐Mesenchymal Transition in Idiopathic Pulmonary Arterial Hypertension

Author

Jason X.-J. Yuan, Tengteng Zhao, Pritesh P. Jain, Ayako Makino, Aleksandra Babicheva, Ning Lai, and Mingmei Xiong

Subjects
Pathology, medicine.medical_specialty, Transition (genetics), business.industry, microRNA, Mesenchymal stem cell, Genetics, medicine, Idiopathic Pulmonary Arterial Hypertension, business, Molecular Biology, Biochemistry, Biotechnology
Published
2020

8. Using Pulmonary Angiogram to Estimate Vascular Remodeling in Mice

Author

Francesca Balistrieri, Ayako Makino, Jason X.-J. Yuan, Pritesh P. Jain, Marisela Rodriguez, Aleksandra Babicheva, Tengteng Zhao, Ning Lai, Mingmei Xiong, Jian Wang, and Shamin Rahimi

Subjects
medicine.medical_specialty, Pulmonary angiogram, business.industry, Internal medicine, Genetics, medicine, Cardiology, business, Molecular Biology, Biochemistry, Biotechnology
Published
2020

9. Calcium Homeostasis Modulator (CALHM1/2) and Pulmonary Arterial Hypertension

Author

Shamin Rahimi, Ayako Makino, Pritesh P. Jain, Ning Lai, Patricia A. Thistlethwaite, Tengteng Zhao, Mingmei Xiong, Francesca Balistrieri, Marisela Rodriguez, Moises Hernandez, Jason X.-J. Yuan, and Aleksandra Babicheva

Subjects
Calcium metabolism, medicine.medical_specialty, Endocrinology, business.industry, Internal medicine, Genetics, Medicine, CALHM1, business, Molecular Biology, Biochemistry, Biotechnology
Published
2020

12. Overactivation of Ca 2+ /Calmodulin‐Dependent Protein Kinase IV and IIδ Contributes to Enhancing Pulmonary Arterial Smooth Muscle Cell Proliferation in Patients with Idiopathic Pulmonary Arterial Hypertension

Author

Kang Wu, Jason X.-J. Yuan, Shane G. Carr, Shanshan Song, and Ziyi Wang

Subjects
medicine.medical_specialty, business.industry, Cell growth, Idiopathic Pulmonary Arterial Hypertension, Biochemistry, Endocrinology, Smooth muscle, CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE IV, Internal medicine, Genetics, Medicine, In patient, business, Molecular Biology, Biotechnology
Published
2018

16. Different Pattern of ATP‐mediated Increases in [Ca 2+ ] cyt Contributes to ATP‐induced Increase in Bcl‐2/Bax Ratio in Lung Cancer Cells But Not in Normal Control Cells

Author

Ayako Makino, Shanshan Song, Jason X.-J. Yuan, Kimberly M. McDermott, and Krista N. Jacobson

Subjects
Tumor microenvironment, Chemistry, Purinergic receptor, Bcl 2 bax, medicine.disease, Biochemistry, Cell function, Cell biology, Genetics, Extracellular, medicine, Lung cancer, Molecular Biology, Normal control, Intracellular, Biotechnology
Abstract

ATP (extracellular messenger) is in much higher concentration in tumor microenvironment. It regulates cell functions through acting on purinergic receptors to activate a series of intracellular sig...

Published
2015

17. MiR‐17~92 promotes hypoxia‐induced pulmonary hypertension by regulating proliferation and contraction of pulmonary arterial smooth muscle cells (LB779)

Author

Guofei Zhou, Qiyuan Zhou, Jason X.-J. Yuan, J. Usha Raj, Haiyang Tang, and Tianji Chen

Subjects
medicine.medical_specialty, Contraction (grammar), business.industry, Wild type, Hypoxia (medical), medicine.disease, Biochemistry, Pulmonary hypertension, Pathogenesis, Endocrinology, Internal medicine, microRNA, Genetics, medicine, medicine.symptom, business, Molecular Biology, Biotechnology, Arterial smooth muscle cells
Abstract

Introduction: Recent studies suggest that microRNAs (miRNAs) play important roles in development and pathogenesis of human diseases. We sought to identify novel miRNAs that may be involved in the pathogenesis of pulmonary arterial hypertension (PAH) and to investigate underlying mechanisms. Methods and Results: We performed miRNA qPCR array using pulmonary arterial smooth muscle cells (PASMC) isolated from lungs of normal donor and PAH patients. We found that all of the six members of the miR-17~92 cluster were down-regulated in PAH PASMCs. In hypoxia-induced PAH mouse model and cultured human PASMCs, we found that short term hypoxia induced miR-17~92 whereas prolonged hypoxia suppressed miR-17~92. We generated a strain of SMC-specific miR-17~92 knockout (sm-17~92-/-) mouse by crossbreeding miR-17~92 fl/fl mice with sm22α-Cre mice and subsequent backcrossing. We exposed 8-10 week old sm-17~92-/- mice along with their wild type littermates to hypoxia (10% O2) or normoxia for five weeks. We showed that knoc...

Published
2014

18. SGLT inhibitors attenuate NO‐dependent vascular relaxation in mouse pulmonary artery (677.3)

Author

Ramon J. Ayon, Ayako Makino, Jason X.-J. Yuan, Ying Han, Anzhi Dai, and Young-Eun Cho

Subjects
medicine.medical_specialty, Relaxation (psychology), SGLT Inhibitors, Chemistry, Type 2 diabetes, Pharmacology, medicine.disease, Biochemistry, Internal medicine, medicine.artery, Pulmonary artery, Genetics, medicine, Cardiology, Cotransporter, Molecular Biology, Biotechnology
Abstract

Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a new class of oral drugs for the treatment of type 2 diabetes and they reduce plasma blood glucose levels by inhibiting renal glucose reabsorp...

Published
2014

19. Shear stress enhance intracellular Ca 2+ in PASMC from patients with idiopathic pulmonary arterial hypertension (1090.13)

Author

Ayako Makino, Kimberly A. Smith, Shanshan Song, Jason X.-J. Yuan, and Haiyang Tang

Subjects
medicine.medical_specialty, business.industry, Cell growth, Idiopathic Pulmonary Arterial Hypertension, Vascular permeability, Biochemistry, medicine.anatomical_structure, Internal medicine, Hypoxic pulmonary vasoconstriction, Genetics, medicine, Vascular resistance, Shear stress, Cardiology, medicine.symptom, business, Molecular Biology, Vasoconstriction, Intracellular, Biotechnology
Abstract

Idiopathic pulmonary arterial hypertension (IPAH) is a fatal and progressive disease which is attributed to elevated pulmonary arterial pressure and pulmonary vascular resistance due in part to sustained pulmonary vasoconstriction and vascular remodeling. Pulmonary arterial smooth muscle cells (PASMC) are normally shielded from exposure to shear stress and sense small flow shear through transmural interstitial flow driven by transvascular pressure differential. However, in the context of endothelial injury or enhanced vascular permeability caused by increased pulmonary arterial pressure, PASMC are exposed to shear stress or to enhanced transmural interstitial flow. Shear stress can increase cytosolic Ca2+ concentration ([Ca2+]cyt). An increase in [Ca2+]cyt in PASMC is a major trigger for vasoconstriction and a key stimulus for cell proliferation, which contribute to vascular remodeling. We show here that shear stress induced increased [Ca2+]cyt in PASMC from patients with IPAH compared with control. Fluid...

Published
2014

20. The crucial role of calcium sensing receptor for hypoxia‐induced pulmonary arterial hypertension in mice (889.2)

Author

Ruby A. Fernandez, Abigail Drennan, Jason X.-J. Yuan, Haiyang Tang, Jiwang Chen, and Shanshan Song

Subjects
medicine.medical_specialty, Chemistry, Stimulus (physiology), Hypoxia (medical), Biochemistry, Cytosol, Endocrinology, Internal medicine, Hypoxic pulmonary vasoconstriction, Genetics, medicine, Calcium-sensing receptor, medicine.symptom, Molecular Biology, Biotechnology, Arterial smooth muscle cells
Abstract

Rationale: An increase in cytosolic free Ca2+ in pulmonary arterial smooth muscle cells (PASMC) is not only a major trigger for pulmonary vasoconstriction but also an important stimulus for PASMC p...

Published
2014

22. microRNA 29b is upregulated in pulmonary artery smooth muscle cells from patients with idiopathic pulmonary arterial hypertension and inhibits K+ channel expression and function

Author

Hisao Yamamura, Jason X.-J. Yuan, Aya Yamamura, Ayako Makino, and Nicole M. Pohl

Subjects
Pathology, medicine.medical_specialty, business.industry, Idiopathic Pulmonary Arterial Hypertension, Biochemistry, MicroRNA 29b, Smooth muscle, Downregulation and upregulation, medicine.artery, Pulmonary artery, Genetics, medicine, business, Molecular Biology, Function (biology), Biotechnology, K channels
Published
2012

25. Kinins and Kinin Receptors in Pulmonary Vasoconstriction and Vascular Remodeling

Author

Randal A. Skidgel, Frank K Kuhr, Irena Levitan, Jason X.-J. Yuan, John W. Christman, and Adrianna M. Zimnicka

Subjects
medicine.medical_specialty, Endocrinology, business.industry, Hypoxic pulmonary vasoconstriction, Internal medicine, Genetics, medicine, Kinin, Receptor, business, Molecular Biology, Biochemistry, Biotechnology
Published
2012

27. Selectively upregulated microRNAs in pulmonary artery smooth muscle cells from patients with idiopathic pulmonary arterial hypertension

Author

Nicole M. Pohl, Jason X.-J. Yuan, and Ayako Makino

Subjects
medicine.medical_specialty, business.industry, Idiopathic Pulmonary Arterial Hypertension, Biochemistry, Downregulation and upregulation, Smooth muscle, medicine.artery, Internal medicine, microRNA, Pulmonary artery, Genetics, medicine, Cardiology, business, Molecular Biology, Biotechnology
Published
2011

30. Role of STIM1 in Coronary Endothelial Cell Dysfunction in Type 1 Diabetic Mice

Author

Jason X.-J. Yuan, Wenlong Han, Irene A. Estrada, Brian T. Scott, Nicholas Fredrick Nolta, Wolfgang H. Dillmann, and Ayako Makino

Subjects
Endothelial stem cell, medicine.medical_specialty, Endocrinology, business.industry, Internal medicine, Genetics, medicine, Diabetic mouse, STIM1, business, Molecular Biology, Biochemistry, Biotechnology
Published
2010

33. Electrophysiological characterization of cells isolated from endarterectomized tissue from patients with chronic thromboembolic pulmonary hypertension (CTEPH)

Author

Jason X.-J. Yuan, Amy L. Firth, Aiko Ogawa, Michael M. Madani, Carmelle V. Remillard, Stuart W. Jamieson, Patricia A. Thistlethwaite, Oleksandr Platoshyn, Weijuan Yao, William R. Auger, and Richard S. Sacks

Subjects
medicine.medical_specialty, Pathology, business.industry, Internal medicine, Genetics, Cardiology, medicine, Chronic thromboembolic pulmonary hypertension, business, Molecular Biology, Biochemistry, Biotechnology
Published
2008

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