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5. Intranasal Leptin Prevents Opioid‐induced Deaths in Mice

Author

Shannon Fonti, Carla Freire, Huy Pho, Luiz Ubirajara Sennes, Lenise Kim, Thomaz Fleury-Curado, and Vsevolod Y. Polotsky

Subjects
medicine.medical_specialty, business.industry, Leptin, Biochemistry, Endocrinology, Opioid, Internal medicine, Genetics, medicine, Nasal administration, business, Molecular Biology, Biotechnology, medicine.drug
Published
2021
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6. Role of Leptin‐TRPM7 Signaling in Carotid Bodies in the Pathogenesis of Sleep‐Disordered Breathing in Obesity

Author

Lenise Kim, Huy Pho, Vsevolod Y. Polotsky, Luu Pham, Rexford S. Ahima, Nishitha Hosamane, Mi Kyung Shin, and Frederick Anokye-Danso

Subjects
medicine.medical_specialty, business.industry, Leptin, medicine.disease, Biochemistry, Obesity, Pathogenesis, Endocrinology, TRPM7, Internal medicine, Genetics, medicine, Sleep disordered breathing, business, Molecular Biology, Biotechnology
Published
2021
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7. DREADD Activation of Leptin Receptor Positive Neurons in The Nucleus of the Solitary Tract During Obstructive Sleep Apnea in Obese Mice

Author

Huy Pho, Carla Freire, David Mendelowitz, Luiz G.S. Branco, Thomaz Fleury-Curado, Vsevolod Y. Polotsky, and Mateus R. Amorim

Subjects
medicine.medical_specialty, Leptin receptor, business.industry, Solitary tract, medicine.disease, Biochemistry, Obstructive sleep apnea, medicine.anatomical_structure, Endocrinology, Internal medicine, Genetics, Medicine, business, Molecular Biology, Nucleus, Biotechnology, Obese Mice
Published
2021
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8. Intranasal Leptin Prevents Opioid Induced Respiratory Depression in Obesity

Author

Lenise Jihe Kim, Vsevolod Y. Polotsky, Luiz Ubirajara Sennes, Jhansi Dyavanapalli, Olga Dergacheva, Huy Pho, Thomaz Fleury-Curado, Stone R Streeter, Xin Wang, and Carla Freire

Subjects
medicine.medical_specialty, business.industry, Leptin, medicine.disease, Biochemistry, Obesity, Endocrinology, Opioid, Internal medicine, Genetics, medicine, Nasal administration, Respiratory system, business, Molecular Biology, Depression (differential diagnoses), Biotechnology, medicine.drug
Abstract

The present disclosure generally relates to compositions and methods of treating opioid-induced respiratory depression in a subject in need thereof, the method comprising administering leptin.

Published
2020
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9. Targeted Retrograde Chemogenetic Approach to Treat Sleep Apnea

Author

Olga Dergacheva, Michael Michaelides, Rachel Lee, Alan Jay Schwartz, Kenneth W. Fishbein, Thomaz Fleury Curado, Michael J Brennick, Lenise Kim, Huy Pho, Jordy Bonaventura, David Mendelowitz, and Vsevolod Y. Polotsky

Subjects
medicine.medical_specialty, business.industry, Internal medicine, Genetics, medicine, Cardiology, Sleep apnea, business, medicine.disease, Molecular Biology, Biochemistry, Biotechnology
Published
2020
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10. Leptin Receptor Blockade Abolished Hypertension and Decreased Hypoxic Ventilatory Response in a Model of Obesity‐Related Hypertension

Author

Lenise Jihe Kim, Sergio Tufik, Vsevolod Y. Polotsky, Huy Pho, Mi Kyung Shin, Laszlo Otvos, and Monica L. Andersen

Subjects
medicine.medical_specialty, Leptin receptor, business.industry, Hypoxic ventilatory response, medicine.disease, Biochemistry, Obesity, Blockade, Endocrinology, Internal medicine, Genetics, Medicine, business, Molecular Biology, Biotechnology
Published
2020
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11. Treatment of Sleep Disordered Breathing With Leptin Loaded Exosomes

Author

Ryo Kojima, Carla Freire, Alexander V. Kabanov, Jacob D. Ramsey, Huy Pho, Vsevolod Y. Polotsky, Slava Berger, and Elena V. Batrakova

Subjects
medicine.medical_specialty, Endocrinology, business.industry, Internal medicine, Leptin, Genetics, Sleep disordered breathing, medicine, business, Molecular Biology, Biochemistry, Microvesicles, Biotechnology
Published
2020
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