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13 results on '"Hiroyuki Kobori"'

2. Augmentation of kidney angiotensinogen expression and urinary angiotensinogen excretion by an intracellular angiotensin II fusion protein (1173.8)

Author

Xiao Li, L. Gabriel Navar, Hiroyuki Kobori, Akemi Katsurada, Ryosuke Satou, and Jia Zhuo

Subjects
medicine.medical_specialty, Kidney, Angiotensin II receptor type 1, Chemistry, Renal cortex, Urinary system, Biochemistry, Angiotensin II, Excretion, medicine.anatomical_structure, Endocrinology, Internal medicine, parasitic diseases, cardiovascular system, Genetics, medicine, Secretion, Molecular Biology, hormones, hormone substitutes, and hormone antagonists, Intracellular, Biotechnology
Abstract

Long-term angiotensin II (ANG II) administration significantly increases ANG II levels in the kidney through two major mechanisms; AT1 receptor-mediated augmentation of angiotensinogen (AGT) expression and uptake of circulating ANG II by the proximal tubule. However, it is not known if intracellular ANG II also stimulates AGT expression and secretion in the proximal tubule of the kidney. In the present study, we performed intrarenal adenoviral transfer of an intracellular cyan fluorescent fusion of ANG II (Ad-sglt2-ECFFP/ANG II) selectively in the proximal tubule using the sodium and glucose co-transporter 2 (sglt2) promoter. AGT mRNA expression in the renal cortex and 24 h urinary AGT excretion were determined 2 and 4 weeks after ECFP/ANG II transfer. ECFP/ANG II was expressed in the proximal tubule in a time-dependent manner, which was associated with significant increases in blood pressure 4 weeks after ECFP/ANG II transfer (p

Published
2014

4. High salt intake exacerbates renal tissue oxidative stress and urinary angiotensinogen excretion during AngII‐dependent hypertension

Author

Hiroyuki Kobori, Michael P. McCormack, Minolfa C. Prieto, L. G. Navar, Dewan S. A. Majid, Lucienne S. Lara, and Sylvia K. Shenouda

Subjects
medicine.medical_specialty, Chemistry, Urinary system, Renal tissue, medicine.disease_cause, Biochemistry, High salt intake, Excretion, Endocrinology, Renal injury, Internal medicine, Genetics, medicine, Molecular Biology, Oxidative stress, Biotechnology
Abstract

High salt (HS) intake inhibits systemic and intrarenal RAS; however, when AngII is not suppressed HS exacerbates hypertension and renal injury. We investigated the effects of HS on the magnitude of...

Published
2010

8. Interferon γ (IFN‐γ) Augments Angiotensinogen (AGT) and Angiotensin Converting Enzyme (ACE) Expression in Rat Mesangial Cells (MCs)

Author

Naro Ohashi, Romer A. Gonzalez-Villalobos, Toshie Saito, Kayoko Miyata, L. Gabriel Navar, Omar W. Acres, Hiroyuki Kobori, Maki Urushihara, Ryousuke Satou, and Akemi Katsurada

Subjects
biology, Chemistry, Genetics, medicine, biology.protein, Interferon gamma, Angiotensin-converting enzyme, Molecular Biology, Biochemistry, Molecular biology, Ifn gamma, Biotechnology, medicine.drug
Published
2009

9. Intrarenal RAS expression during Ang II‐infusions and ACE inhibition

Author

Romer A. Gonzalez-Villalobos, Naro Ohashi, Minolfa C. Prieto-Carrasquero, Akemi Katsurada, L. Gabriel Navar, Hiroyuki Kobori, Ryousuke Satou, Laura Semprun-Prieto, and G. Michael Upchurch

Subjects
Chemistry, Genetics, Pharmacology, Molecular Biology, Biochemistry, Ace inhibition, Biotechnology
Published
2009

10. Increased urinary excretion of angiotensinogen(AGT) in type II diabetic mice

Author

Sungmi Park, Lisa M. Harrison-Bernard, Hiroyuki Kobori, Benjamin J. Bivona, Dale M. Seth, and Souad Belmadani

Subjects
medicine.medical_specialty, Urinary excretion, Endocrinology, business.industry, Internal medicine, Genetics, medicine, Diabetic mouse, business, Molecular Biology, Biochemistry, Biotechnology
Published
2008

11. Role of Angiotensin II internalization in the activation of Proximal Tubule Angiotensinogen

Author

Ryousuke Satou, L. Gabriel Navar, Hiroyuki Kobori, and Romer A. Gonzalez-Villalobos

Subjects
medicine.medical_specialty, Chemistry, media_common.quotation_subject, Biochemistry, Angiotensin II, Endocrinology, medicine.anatomical_structure, Internal medicine, Genetics, medicine, Proximal tubule, Internalization, Molecular Biology, Biotechnology, media_common
Published
2008

12. Megalin mediates the uptake of angiotensin II in proximal tubule cells

Author

Romer A. Gonzalez-Villalobos, Hiroyuki Kobori, Ryousuke Satou, Timothy G. Hammond, Akemi Katsurada, and L. G. Navar

Subjects
medicine.medical_specialty, medicine.anatomical_structure, Endocrinology, Chemistry, Internal medicine, Genetics, medicine, Proximal tubule, Molecular Biology, Biochemistry, Angiotensin II, Biotechnology
Published
2007

13. Effects of Aldosterone Receptor Blockade on Collecting Duct Renin in Normotensive and Hypertensive Rats

Author

Melissa Evans‐Vallas, Hiroyuki Kobori, Dale M. Seth, Javier Pagan, L. Gabriel Navar, Rudy M. Ortiz, and Minolfa C. Prieto-Carrasquero

Subjects
medicine.medical_specialty, business.industry, Biochemistry, Blockade, Endocrinology, Mineralocorticoid receptor, medicine.anatomical_structure, Internal medicine, Renin–angiotensin system, Genetics, Medicine, business, Molecular Biology, Duct (anatomy), Biotechnology
Published
2006

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