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2. Molecular definitions of autophagy and related processes

Author

Galluzzi, Lorenzo, Baehrecke, Eric H, Ballabio, Andrea, Boya, Patricia, Pedro, José Manuel Bravo‐San, Cecconi, Francesco, Choi, Augustine M, Chu, Charleen T, Codogno, Patrice, Colombo, Maria Isabel, Cuervo, Ana Maria, Debnath, Jayanta, Deretic, Vojo, Dikic, Ivan, Eskelinen, Eeva‐Liisa, Fimia, Gian Maria, Fulda, Simone, Gewirtz, David A, Green, Douglas R, Hansen, Malene, Harper, J Wade, Jäättelä, Marja, Johansen, Terje, Juhasz, Gabor, Kimmelman, Alec C, Kraft, Claudine, Ktistakis, Nicholas T, Kumar, Sharad, Levine, Beth, Lopez‐Otin, Carlos, Madeo, Frank, Martens, Sascha, Martinez, Jennifer, Melendez, Alicia, Mizushima, Noboru, Münz, Christian, Murphy, Leon O, Penninger, Josef M, Piacentini, Mauro, Reggiori, Fulvio, Rubinsztein, David C, Ryan, Kevin M, Santambrogio, Laura, Scorrano, Luca, Simon, Anna Katharina, Simon, Hans‐Uwe, Simonsen, Anne, Tavernarakis, Nektarios, Tooze, Sharon A, Yoshimori, Tamotsu, Yuan, Junying, Yue, Zhenyu, Zhong, Qing, and Kroemer, Guido

Subjects
Animals, Autophagy, Caenorhabditis elegans, Drosophila melanogaster, Gene Regulatory Networks, Mice, Saccharomyces cerevisiae, Terminology as Topic, chaperone-mediated autophagy, LC3-associated phagocytosis, microautophagy, mitophagy, xenophagy, LC3‐associated phagocytosis, chaperone‐mediated autophagy, Biological Sciences, Information and Computing Sciences, Medical and Health Sciences, Developmental Biology
Abstract

Over the past two decades, the molecular machinery that underlies autophagic responses has been characterized with ever increasing precision in multiple model organisms. Moreover, it has become clear that autophagy and autophagy-related processes have profound implications for human pathophysiology. However, considerable confusion persists about the use of appropriate terms to indicate specific types of autophagy and some components of the autophagy machinery, which may have detrimental effects on the expansion of the field. Driven by the overt recognition of such a potential obstacle, a panel of leading experts in the field attempts here to define several autophagy-related terms based on specific biochemical features. The ultimate objective of this collaborative exchange is to formulate recommendations that facilitate the dissemination of knowledge within and outside the field of autophagy research.

Published
2017

3. Autophagy in malignant transformation and cancer progression

Author

Galluzzi, Lorenzo, Pietrocola, Federico, Bravo-San Pedro, José Manuel, Amaravadi, Ravi K, Baehrecke, Eric H, Cecconi, Francesco, Codogno, Patrice, Debnath, Jayanta, Gewirtz, David A, Karantza, Vassiliki, Kimmelman, Alec, Kumar, Sharad, Levine, Beth, Maiuri, Maria Chiara, Martin, Seamus J, Penninger, Josef, Piacentini, Mauro, Rubinsztein, David C, Simon, Hans-Uwe, Simonsen, Anne, Thorburn, Andrew M, Velasco, Guillermo, Ryan, Kevin M, and Kroemer, Guido

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cancer, Brain Disorders, Rare Diseases, Brain Cancer, Aetiology, 2.1 Biological and endogenous factors, Animals, Autophagy, Cell Transformation, Neoplastic, Humans, Neoplasms, Tumor Escape, Tumor Suppressor Proteins, adaptive stress responses, Beclin 1, inflammation, KRAS, mitophagy, Biological Sciences, Information and Computing Sciences, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences
Abstract

Autophagy plays a key role in the maintenance of cellular homeostasis. In healthy cells, such a homeostatic activity constitutes a robust barrier against malignant transformation. Accordingly, many oncoproteins inhibit, and several oncosuppressor proteins promote, autophagy. Moreover, autophagy is required for optimal anticancer immunosurveillance. In neoplastic cells, however, autophagic responses constitute a means to cope with intracellular and environmental stress, thus favoring tumor progression. This implies that at least in some cases, oncogenesis proceeds along with a temporary inhibition of autophagy or a gain of molecular functions that antagonize its oncosuppressive activity. Here, we discuss the differential impact of autophagy on distinct phases of tumorigenesis and the implications of this concept for the use of autophagy modulators in cancer therapy.

Published
2015

4. Autophagy in major human diseases

Author

Klionsky, Daniel J, Petroni, Giulia, Amaravadi, Ravi K, Baehrecke, Eric H, Ballabio, Andrea, Boya, Patricia, Bravo‐San Pedro, José Manuel, Cadwell, Ken, Cecconi, Francesco, Choi, Augustine M K, Choi, Mary E, Chu, Charleen T, Codogno, Patrice, Colombo, Maria Isabel, Cuervo, Ana Maria, Deretic, Vojo, Dikic, Ivan, Elazar, Zvulun, Eskelinen, Eeva‐Liisa, Fimia, Gian Maria, Gewirtz, David A, Green, Douglas R, Hansen, Malene, Jäättelä, Marja, Johansen, Terje, Juhász, Gábor, Karantza, Vassiliki, Kraft, Claudine, Kroemer, Guido, Ktistakis, Nicholas T, Kumar, Sharad, Lopez‐Otin, Carlos, Macleod, Kay F, Madeo, Frank, Martinez, Jennifer, Meléndez, Alicia, Mizushima, Noboru, Münz, Christian, Penninger, Josef M, Perera, Rushika M, Piacentini, Mauro, Reggiori, Fulvio, Rubinsztein, David C, Ryan, Kevin M, Sadoshima, Junichi, Santambrogio, Laura, Scorrano, Luca, Simon, Hans‐Uwe, Simon, Anna Katharina, Simonsen, Anne, Stolz, Alexandra, Tavernarakis, Nektarios, Tooze, Sharon A, Yoshimori, Tamotsu, Yuan, Junying, Yue, Zhenyu, Zhong, Qing, Galluzzi, Lorenzo, and Pietrocola, Federico

Published
2021
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7. Unsaturated fatty acids induce non‐canonical autophagy

Author

Niso‐Santano, Mireia, Malik, Shoaib Ahmad, Pietrocola, Federico, Bravo‐San Pedro, José Manuel, Mariño, Guillermo, Cianfanelli, Valentina, Ben‐Younès, Amena, Troncoso, Rodrigo, Markaki, Maria, Sica, Valentina, Izzo, Valentina, Chaba, Kariman, Bauvy, Chantal, Dupont, Nicolas, Kepp, Oliver, Rockenfeller, Patrick, Wolinski, Heimo, Madeo, Frank, Lavandero, Sergio, Codogno, Patrice, Harper, Francis, Pierron, Gérard, Tavernarakis, Nektarios, Cecconi, Francesco, Maiuri, Maria Chiara, Galluzzi, Lorenzo, and Kroemer, Guido

Published
2015
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9. Inhibition of autophagy by TAB2 and TAB3

Author

Criollo, Alfredo, Niso‐Santano, Mireia, Malik, Shoaib Ahmad, Michaud, Mickael, Morselli, Eugenia, Mariño, Guillermo, Lachkar, Sylvie, Arkhipenko, Alexander V, Harper, Francis, Pierron, Gérard, Rain, Jean‐Christophe, Ninomiya‐Tsuji, Jun, Fuentes, José M, Lavandero, Sergio, Galluzzi, Lorenzo, Maiuri, Maria Chiara, and Kroemer, Guido

Published
2011
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10. A yeast BH3‐only protein mediates the mitochondrial pathway of apoptosis

Author

Büttner, Sabrina, Ruli, Doris, Vögtle, F‐Nora, Galluzzi, Lorenzo, Moitzi, Barbara, Eisenberg, Tobias, Kepp, Oliver, Habernig, Lukas, Carmona‐Gutierrez, Didac, Rockenfeller, Patrick, Laun, Peter, Breitenbach, Michael, Khoury, Chamel, Fröhlich, Kai‐Uwe, Rechberger, Gerald, Meisinger, Chris, Kroemer, Guido, and Madeo, Frank

Published
2011
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12. The IKK complex contributes to the induction of autophagy

Author

Criollo, Alfredo, Senovilla, Laura, Authier, Hélène, Maiuri, Maria Chiara, Morselli, Eugenia, Vitale, Ilio, Kepp, Oliver, Tasdemir, Ezgi, Galluzzi, Lorenzo, Shen, Shensi, Tailler, Maximilien, Delahaye, Nicolas, Tesniere, Antoine, De Stefano, Daniela, Younes, Aména Ben, Harper, Francis, Pierron, Gérard, Lavandero, Sergio, Zitvogel, Laurence, Israel, Alain, Baud, Véronique, and Kroemer, Guido

Published
2010
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