1. Application of Rh(I)/Bicyclo[2.2.1]heptadiene Catalysts to the Enantioselective Synthesis of Chiral Amines
- Author
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Yu-Yi Cheng, Wei-Sian Li, and Hsyueh Liang Wu
- Subjects
Bicyclic molecule ,Personal account ,Chemistry ,General Chemical Engineering ,Imine ,Enantioselective synthesis ,Stereoisomerism ,General Chemistry ,Ligands ,Biochemistry ,Combinatorial chemistry ,Catalysis ,Adduct ,chemistry.chemical_compound ,Reagent ,Materials Chemistry ,Molecule ,Imines ,Amines - Abstract
The development of efficient synthetic methods for accessing enantioenriched α-chiral amines is of great importance in the disciplines of medicinal and synthetic organic chemistry. Enantioselective Rh-catalyzed 1,2-addition reactions to activated imine derivatives are regarded as useful protocols for forming α-chiral amines. This personal account outlines our efforts to develop chiral bicyclo[2.2.1]heptadiene ligands for Rh-catalyzed asymmetric additions of various organoboron reagents to a wide range of imine derivatives. Transformations of the thus-obtained adducts into known natural products or molecules of pharmaceutical importance serve to confirm their synthetic usefulness.
- Published
- 2021
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