1. The origin and significance of macrophages in thoracic duct lymph
- Author
-
Bruce Joseph Roser
- Subjects
Pathology ,medicine.medical_specialty ,Adoptive cell transfer ,Time Factors ,Lymphocyte ,Fistula ,Clinical Biochemistry ,Immunology ,Population ,Cell Separation ,Thoracic duct ,Catheterization ,Thoracic Duct ,Cell Movement ,medicine ,Thoracic duct lymph ,Animals ,Ascitic Fluid ,Lymphocytes ,education ,education.field_of_study ,business.industry ,General surgery ,Macrophages ,Cell Biology ,General Medicine ,medicine.disease ,Rats ,medicine.anatomical_structure ,Lymph ,Foreign body ,business - Abstract
Efferent lymph collected from a thoracic duct fistula initially contains no macrophages. However, the surgical procedures used to insert plastic cannulae into efferent lymphatics incite a vigorous foreign body reaction leading to the contamination of collected lymph with significant numbers of these cells. A sensitive and specific assay for the presence of macrophages in lymphocyte populations was used to quantitate the degree of contamination in rats bearing thoracic duct cannulae. The origin of some of these contaminant cells from the peritoneal macorphage population was established by adoptive transfer of labelled peritoneal cells to cannulated recipients.
- Published
- 1976