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Giant juvenile fibroadenomas are usually seen as rare variants of fibroadenomas in adolescents as unilateral solitary masses that may be managed by surgical excision with conservation of normal breast tissue. We report a case of a premenarchal 13-year-old female presenting with bilateral multifocal giant juvenile fibroadenomas requiring essentially bilateral subtotal nipple sparing mastectomies. Surgical evaluation revealed replacement of normal breast tissue on the right side. She then had development of two additional right-sided fibroadenomas requiring excision.