1. Effects of HIV triple therapy on methadone levels
- Author
-
Edward Nunes, Evaristo O. Akerele, Herbert Kleber, Frances Rudnick Levin, and Ronald Brady
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Anti-HIV Agents ,Human immunodeficiency virus (HIV) ,Medicine (miscellaneous) ,HIV Infections ,medicine.disease_cause ,Internal medicine ,medicine ,Potency ,Humans ,Drug Interactions ,Aged ,Aids patients ,Acquired Immunodeficiency Syndrome ,business.industry ,Heroin Dependence ,Middle Aged ,Psychiatry and Mental health ,Clinical Psychology ,Cross-Sectional Studies ,Anesthesia ,Hiv patients ,Drug Therapy, Combination ,Female ,business ,Methadone ,medicine.drug - Abstract
There is a belief among methadone patients that triple therapy for HIV reduces methadone potency. This cross-sectional study compared the rate of methadone metabolism (peak-trough blood levels) in two groups of methadone-maintained patients, AIDS patients receiving triple therapy (N = 17), and HIV patients without triple therapy (N = 19). These preliminary findings suggest that triple therapy may increase the rate of methadone metabolism, though further studies are warranted.
- Published
- 2003