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Your search keyword '"Kanyi, Henry M."' showing total 3 results
Start Over Author "Kanyi, Henry M." Journal the american journal of tropical medicine and hygiene
3 results on '"Kanyi, Henry M."'

1. Integrated Cross-Sectional Multiplex Serosurveillance of IgG Antibody Responses to Parasitic Diseases and Vaccines in Coastal Kenya.

Author

Njenga, Sammy M, Kanyi, Henry M, Arnold, Benjamin F, Matendechero, Sultani H, Onsongo, Joyce K, Won, Kimberly Y, and Priest, Jeffrey W

Subjects
Humans, Diphtheria, Tetanus, Measles, Parasitic Diseases, Immunoglobulin G, Diphtheria-Tetanus Vaccine, Measles Vaccine, Antibodies, Bacterial, Antibodies, Helminth, Antibodies, Protozoan, Antibodies, Viral, Seroepidemiologic Studies, Kenya, Antibodies, Bacterial, Helminth, Protozoan, Viral, Tropical Medicine, Medical and Health Sciences
Abstract

Accurate and cost-effective identification of areas where co-endemic infections occur would enable public health managers to identify opportunities for implementation of integrated control programs. Dried blood spots collected during cross-sectional lymphatic filariasis surveys in coastal Kenya were used for exploratory integrated detection of IgG antibodies against antigens from several parasitic infections (Wuchereria bancrofti, Schistosoma mansoni, Plasmodium spp., Ascaris lumbricoides, and Strongyloides stercoralis) as well as for detection of responses to immunizing agents used against vaccine-preventable diseases (VPDs) (measles, diphtheria, and tetanus) using a multiplex bead assay (MBA) platform. High heterogeneity was observed in antibody responses by pathogen and antigen across the sentinel sites. Antibody seroprevalence against filarial antigens were generally higher in Ndau Island (P < 0.0001), which also had the highest prevalence of filarial antigenemia compared with other communities. Antibody responses to the Plasmodium species antigens circumsporozoite protein (CSP) and merozoite surface protein-1 (MSP-1)19 were higher in Kilifi and Kwale counties, with Jaribuni community showing higher overall mean seroprevalence (P < 0.0001). Kimorigo community in Taita-Taveta County was the only area where antibody responses against S. mansoni Sm25 recombinant antigen were detected. Seroprevalence rates to Strongyloides antigen NIE ranged between 3% and 26%, and there was high heterogeneity in immune responses against an Ascaris antigen among the study communities. Differences were observed between communities in terms of seroprevalence to VPDs. Seroprotection to tetanus was generally lower in Kwale County than in other counties. This study has demonstrated that MBA holds promise for rapid integrated monitoring of trends of infections of public health importance in endemic areas.

Published
2020

2. Mapping of Podoconiosis Cases and Risk Factors in Kenya: A Nationwide Cross-sectional Study

Author

Sultani, Hadley Matendechero, primary, Okoyo, Collins, additional, Kanyi, Henry M., additional, Njenga, Sammy M., additional, Omondi, Wyckliff P., additional, Ayagah, Isabella, additional, Buliva, Morris, additional, Ngere, Isaac, additional, Gachohi, John, additional, Muli, Jacinta, additional, Newport, Melanie J., additional, and Deribe, Kebede, additional

Published
2021
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3. Multiplex Serologic Assessment of Schistosomiasis in Western Kenya: Antibody Responses in Preschool Aged Children as a Measure of Reduced Transmission

Author

Won, Kimberly Y., Kanyi, Henry M., Mwende, Faith M., Wiegand, Ryan E., Goodhew, E. Brook, Priest, Jeffrey W., Lee, Yeuk-Mui, Njenga, Sammy M., Secor, W. Evan, Lammie, Patrick J., and Odiere, Maurice R.

Subjects
Male, Endemic Diseases, Antibodies, Helminth, Infant, Articles, Schistosoma mansoni, Kenya, Cross-Sectional Studies, Antigens, Helminth, Child, Preschool, Antibody Formation, Prevalence, Animals, Cluster Analysis, Humans, Schistosomiasis, Female, Prospective Studies, Child
Abstract

Currently, impact of schistosomiasis control programs in Schistosoma mansoni–endemic areas is monitored primarily by assessment of parasitologic indicators only. Our study was conducted to evaluate the use of antibody responses as a way to measure the impact of schistosomiasis control programs. A total of 3,612 serum samples collected at three time points from children 1–5 years of age were tested for antibody responses to two schistosome antigens (soluble egg antigen [SEA] and Sm25) by multiplex bead assay. The overall prevalence of antibody responses to SEA was high at baseline (50.0%). After one round of mass drug administration (MDA), there was minimal change in odds of SEA positivity (odds ratio [OR] = 1.02, confidence interval [CI] = 0.79–1.32, P = 0.89). However, after two rounds of treatment, there was a slight decrease in odds of SEA positivity (OR = 0.80, CI = 0.63–1.02, P = 0.08). In contrast to the SEA results, prevalence of antibody responses to Sm25 was lowest at baseline (14.1%) and higher in years 2 (19.8%) and 3 (18.4%). After one round of MDA, odds of Sm25 positivity increased significantly (OR = 1.51, CI = 1.14–2.02, P = 0.005) and remained significantly higher than baseline after two rounds of MDA (OR = 1.37, CI = 1.07–1.76, P = 0.01). There was a significant decrease in the proportion of 1-year-olds with positive SEA responses from 33.1% in year 1 to 13.2% in year 3 and a corresponding decrease in the odds (OR = 3.25, CI = 1.75–6.08, P < 0.001). These results provide preliminary evidence that schistosomiasis program impact can be monitored using serologic responses.

Published
2017

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