1. GENETIC DIVERSITY AND STRUCTURE OF AFRICAN PLASMODIUM FALCIPARUM POPULATIONS IN URBAN AND RURAL AREAS
- Author
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Christophe Rogier, Serge-Brice Assi, Housem Bouchiba, Marie-Claire Henry, Bruno Pradines, Eric Garnotel, Thierry Fusai, Mohamed Ali Kamil, Odile Puijalon, Patrick Durand, Eric Adehossi, Hervé Bogreau, François Renaud, Philippe Parola, and Boubacar Wade
- Subjects
Rural Population ,Linkage disequilibrium ,Genotype ,Urban Population ,Plasmodium falciparum ,STRUCTURE DE POPULATION ,Polymerase Chain Reaction ,Linkage Disequilibrium ,Virology ,parasitic diseases ,ETUDE COMPARATIVE ,TECHNIQUE PCR ,medicine ,Animals ,Humans ,MARQUEUR MOLECULAIRE ,Genetic variability ,Malaria, Falciparum ,PARASITE ,VARIABILITE GENETIQUE ,MILIEU URBAIN ,DNA Primers ,Genetic diversity ,Geography ,biology ,Ecology ,Genetic Variation ,PALUDISME ,DIVERSITE GENETIQUE ,biology.organism_classification ,medicine.disease ,GENOTYPE ,Infectious Diseases ,Africa ,VARIATION SPATIALE ,POLYMORPHISME GENETIQUE ,Biological dispersal ,Parasitology ,ANALYSE GENETIQUE ,Rural area ,MILIEU RURAL ,Malaria ,Microsatellite Repeats - Abstract
The genetic variability and population structure of Plasmodium falciparum are key factors in malaria control strategies. Studies have suggested no P. falciparum population structure although linkage disequilibrium was observed in some African areas. We have assessed length polymorphism at 6-22 microsatellites in four urban and rural sites (Djibouti, Dakar, Niamey, and Zouan-Hounien, n = 240 blood samples). Results have shown a P. falciparum population structure in Africa (Fst = 0.17-0.24), lower genetic diversity in Djibouti (He = 0.53) than in the other sites (He = 0.73-0.76), and 3) significant linkage disequilibrium in Djibouti. These results could be related to geographic isolation and low flow of parasites between sites. They also suggest a potential effect of rural suburbs to generate genetic diversity in towns. This could affect the dispersal of selected drug resistance and should be considered when adapting urban malaria control strategies.
- Published
- 2006