1. It's sooner than you think: Blunt solid organ injury patients are already hypercoagulable upon hospital admission - Results of a bi-institutional, prospective study
- Author
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Hunter B. Moore, Eduardo Gonzalez, Mitchell J. Cohen, Annika B. Kay, Ernest E. Moore, Thomas W. White, Julia R. Coleman, Sarah Majercik, and Fredric M. Pieracci
- Subjects
Adult ,Male ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,Wounds, Nonpenetrating ,Tissue plasminogen activator ,Article ,Time-to-Treatment ,03 medical and health sciences ,0302 clinical medicine ,Blunt ,Trauma Centers ,Intensive care ,Fibrinolysis ,medicine ,Humans ,Prospective Studies ,Prospective cohort study ,business.industry ,Anticoagulants ,030208 emergency & critical care medicine ,Venous Thromboembolism ,General Medicine ,Blood Coagulation Disorders ,Middle Aged ,medicine.disease ,Thrombosis ,Thrombelastography ,Anesthesia ,Chemoprophylaxis ,Hospital admission ,Female ,Surgery ,business ,medicine.drug - Abstract
Introduction The optimal time to initiate venous thromboembolism (VTE) chemoprophylaxis in blunt solid organ injury (BSOI) patients is debated. We hypothesize that 1) BSOI patients are hypercoagulable within 12 h of injury and 2) hypercoagulability dominates in patients who develop clot complications (CC). Material and methods This is a prospective study of BSOI patients admitted to two Level-1 Trauma Centers’ trauma intensive care units (ICU). Serial kaolin thrombelastography (TEG) and tissue plasminogen activator (tPA)-challenge TEGs were performed. CC included VTE and cerebrovascular accidents. Results On ICU admission, all patients (n = 95) were hypercoagulable, 58% were in fibrinolysis shutdown, and 50% of patients were tPA-resistant. Twelve patients (13%) developed CC. Compared to those without CC, they demonstrated decreased fibrinolysis at 12 h and higher clot strength at 48 h Conclusions BSOI patients are universally hypercoagulable upon ICU admission. VTE chemoprophylaxis should be started immediately in BSOI patients with hypercoagulability on TEG.
- Published
- 2019
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