1. Perioperative antibiotics should be used for placement of implanted central venous ports: A propensity analysis evaluating risk
- Author
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Megan E. Bowen, Mary C. Mone, Edward W. Nelson, Courtney L. Scaife, Chong Zhang, Angela P. Presson, and Douglas S. Swords
- Subjects
Adult ,Male ,Catheterization, Central Venous ,endocrine system ,medicine.medical_specialty ,Adolescent ,Population ,Single Center ,Young Adult ,03 medical and health sciences ,Catheters, Indwelling ,0302 clinical medicine ,medicine ,Humans ,030212 general & internal medicine ,Antibiotic prophylaxis ,Propensity Score ,education ,Aged ,Retrospective Studies ,Aged, 80 and over ,education.field_of_study ,business.industry ,Incidence (epidemiology) ,Confounding ,Retrospective cohort study ,General Medicine ,Perioperative ,Antibiotic Prophylaxis ,Middle Aged ,Anti-Bacterial Agents ,Catheter-Related Infections ,030220 oncology & carcinogenesis ,Propensity score matching ,Emergency medicine ,Female ,Surgery ,business - Abstract
Objective To quantify risk for CRI based on PABX use in CVAP placement for cancer patients. Summary background data : Central venous access ports (CVAP) are totally implanted devices used for chemotherapy. There is a temporal risk for catheter related infection (CRI) to insertion and perioperative prophylactic antibiotics (PABX) use is a contested issue among practitioners. Methods Data was collected from a single center, academic oncology center. Treatment with a perioperative PABX was compared to non-treatment, to examine the incidence of 14-day CRI. Propensity scores with matched weights controlled for confounding, using 15 demographic, procedural and clinical variables. Results From 2007 to 2012, 1,091 CVAP were placed, where 59.7 % received PABX. The 14-day CRI rate was 0.82%, with 78% of those not receiving PABX. While results did not achieve statistical significance, use of PABX was associated with a 58% reduction in the odds of a 14-day CRI (OR = 0.42, 95% CI: 0.08-2.24, p = 0.31). Conclusion The findings suggest a reduction in early CRI with the use of PABX. Since CRI treatment can range from a course of oral antibiotics, port removal, to hospital admission, we suggest clinicians consider these data when considering PABX in this high-risk population.
- Published
- 2018