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Start Over Author "Luisa Rios-Avila" Journal the american journal of clinical nutrition
1 results on '"Luisa Rios-Avila"'

1. Pyridoxine supplementation does not alter in vivo kinetics of one-carbon metabolism but modifies patterns of one-carbon and tryptophan metabolites in vitamin B-6–insufficient oral contraceptive users

Author

Maria Ralat, Øivind Midttun, Peter W. Stacpoole, Per Magne Ueland, Jesse F. Gregory, Luisa Rios-Avila, Yueh-Yun Chi, and Bonnie S. Coats

Subjects
Vitamin, medicine.medical_specialty, Nutrition and Dietetics, Methionine, Homocysteine, biology, Metabolite, Medicine (miscellaneous), Pyridoxine, Cystathionine beta synthase, chemistry.chemical_compound, Endocrinology, chemistry, Biochemistry, Internal medicine, medicine, biology.protein, Pyridoxal, Kynurenine, medicine.drug
Abstract

Background: Low chronic vitamin B-6 status can occur in a subset of women who use oral contraceptives (OCs) with uncertain metabolic consequences. An insufficiency of cellular pyridoxal 5′-phosphate (PLP), which is the coenzyme form of vitamin B-6, may impair many metabolic processes including one-carbon and tryptophan metabolism. Objective: We investigated the effects of vitamin B-6 supplementation on the in vivo kinetics of one-carbon metabolism and the concentration of one-carbon and tryptophan metabolites in vitamin B-6–deficient OC users. Design: A primed, constant infusion of [13C5]methionine, [3-13C]serine, and [2H3]leucine was performed on 10 OC users (20–40 y old; plasma PLP concentrations

Published
2015

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