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Your search keyword '"Wanjun Zheng"' showing total 4 results
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4 results on '"Wanjun Zheng"'

1. An unequivocal synthesis of the ring-A,B dihydropyrromethenone of phytochrome

Author

Jiasheng Guo, Peter A. Jacobi, and Wanjun Zheng

Subjects
chemistry.chemical_classification, Phytochrome, Stereochemistry, Chemistry, Organic Chemistry, Drug Discovery, Nanotechnology, Ring (chemistry), Biochemistry, Lactone
Abstract

Dihydropyrromethenone 1b (R = p -methoxybenzyl), a potential precursor for the synthesis of phytochrome ( 3 ), has been prepared in enantiomerically pure form beginning with the homochiral acetylenic lactone 18 .

Published
1995

2. A versatile, synthesis of β-amino acids using the Nicholas reaction. I. Application to β-lactams of the carbapenem class

Author

Peter A. Jacobi and Wanjun Zheng

Subjects
chemistry.chemical_classification, Carbapenem, Chemistry, Stereochemistry, Organic Chemistry, Nicholas reaction, Sequence (biology), Biochemistry, Amino acid, chemistry.chemical_compound, Drug Discovery, Lactam, medicine, Stereoselectivity, Aliphatic compound, Curtius rearrangement, medicine.drug
Abstract

Homochiral acetylenic acids of general structure 10 , prepared using the Schreiber modification of the Nicholas reaction, have been converted to β-amino acid derivatives of type 11 by a two steps sequence involving Curtius rearrangement followed by oxidative cleavage of the acetylenic bond. Amino acid derivatives 11 are excellent precursors for β-lactams of the carbapenem class.

Published
1993

3. A versatile synthesis of β-amino acids using the nicholas reaction. II. Formal total synthesis of thienamycin

Author

Wanjun Zheng and Peter A. Jacobi

Subjects
chemistry.chemical_classification, Chemistry, Stereochemistry, Organic Chemistry, Diol, Total synthesis, Nicholas reaction, Biochemistry, Amino acid, chemistry.chemical_compound, Thienamycin, Drug Discovery, Lactam, Protecting group, Curtius rearrangement
Abstract

Homochiral acetylenic acid 26 , prepared using the Schreiber modification of the Nicholas reaction, has been converted to β-amino acid derivative 28 by a two step sequence involving Curtius rearrangement fallowed by oxidative clevage of the acetylenic bond. Amino acid derivative 28 was then converted to thienamycin (β12) precursor 30 by cyclization with DCC followed by epmerization.

Published
1993

4. A novel synthesis of juncusol

Author

Peter A. Jacobi and Wanjun Zheng

Subjects
chemistry.chemical_compound, Electrocyclic reaction, chemistry, Organic Chemistry, Drug Discovery, Organic chemistry, Phenols, Biochemistry, Derivative (chemistry)
Abstract

Juncusol (7) has been prepared by a novel electrocyclization process beginning with the known β-tetralone derivative 9.

Published
1991

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