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17 results on '"Peter T. Murphy"'

1. Synthesis of polycarpine, a cytotoxic sulfur-containing alkaloid from the ascidian Polycarpa aurata, and related compounds

Author

V. L. Novikov, Oleg S. Radchenko, George B. Elyakov, Peter T. Murphy, and Richard H. Willis

Subjects
Natural product, biology, Stereochemistry, Disulfide Linkage, Alkaloid, Organic Chemistry, Polycarpa aurata, biology.organism_classification, Biochemistry, chemistry.chemical_compound, Acetic acid, chemistry, Bromide, Yield (chemistry), Drug Discovery, Organic chemistry, Thiazole
Abstract

Polycarpine 1 , a highly cytotoxic marine natural product, has been synthesized in three steps from p-methoxyphenacyl bromide 4 in 57% overall yield. The key reaction for construction of the symmetrically substituted disulfide linkage of polycarpine is the treatment of 2-amino-4-(4-methoxyphenyl)-1-methylimidazole 17 with S2Cl2 in acetic acid. In a similar way ten related compounds, including three thiazole analogues, have been prepared. Most of them exhibit high cytotoxic activities against an array of human cancer cell lines.

Published
1997

2. Echinoclasterol sulfate phenethylammonium salt, a unique steroid sulfate from the marine sponge, Echinoclathria subhispida

Author

Richard H. Willis, Peter T. Murphy, Joe Baker, Nobuhiro Fusetani, Shigeki Matsunaga, Hong yu Li, and Hirota Fujiki

Subjects
chemistry.chemical_classification, biology, medicine.medical_treatment, Organic Chemistry, Salt (chemistry), Biological activity, biology.organism_classification, Biochemistry, Steroid, chemistry.chemical_compound, Sponge, chemistry, Drug Discovery, medicine, Steroid sulfate, Sulfate, Mortierella, Cytotoxicity, Nuclear chemistry
Abstract

A phenethylammonium salt of a new steroid sulfate, echinoclasterol sulfate (1) has been isolated from the marine sponge, Echinoclathria subhispida. The structure was determined by interpretation of spectral data including 2D NMR and FABMS. It exhibited antifungal activity against Mortierella ramannianus, and cytotoxicity against PC-9 human lung cancer cells.

Published
1993

5. A new diterpene from the sponge

Author

John J. Daly, Rymantas Kazlauskas, Robert J. Wells, and Peter T. Murphy

Subjects
chemistry.chemical_compound, Sponge, chemistry, biology, Organic Chemistry, Drug Discovery, Organic chemistry, Diterpene, biology.organism_classification, Biochemistry
Published
1979

6. Two sesquiterpene furans with new carbocyclic ring systems and related thiol acetates from a species of the sponge genus

Author

Rymantas Kazlauskas, Robert J. Wells, Peter T. Murphy, John J. Daly, and Peter Schönholzer

Subjects
chemistry.chemical_classification, biology, Stereochemistry, Organic Chemistry, Sesquiterpene, biology.organism_classification, Ring (chemistry), Biochemistry, chemistry.chemical_compound, Sponge, chemistry, Genus, Drug Discovery, Thiol, Organic chemistry
Published
1978

7. Aplysinopsin, a new tryptophan derivative from a sponge

Author

Robert J. Wells, Rymantas Kazlauskas, Ronald J. Quinn, and Peter T. Murphy

Subjects
Aplysinopsin, Sponge, chemistry.chemical_compound, biology, Chemistry, Stereochemistry, Organic Chemistry, Drug Discovery, Tryptophan, biology.organism_classification, Biochemistry, Derivative (chemistry)
Published
1977

8. Heteronemin, a new scalarin type sesterterpene from the sponge

Author

Peter T. Murphy, Robert J. Wells, Ronald J. Quinn, and Rymantas Kazlauskas

Subjects
Sponge, biology, Chemistry, Stereochemistry, Organic Chemistry, Drug Discovery, biology.organism_classification, Biochemistry, Heteronemin
Published
1976

9. New diterpene isocyanides from a sponge

Author

Robert J. Wells, Rymantas Kazlauskas, John F. Blount, and Peter T. Murphy

Subjects
chemistry.chemical_compound, Sponge, biology, Chemistry, Stereochemistry, Organic Chemistry, Drug Discovery, Diterpene, biology.organism_classification, Biochemistry, Diisocyanoadociane
Abstract

Six new diterpene isocyanides have been isolated from a sponge ( Adocia sp.). Their structures support the biosynthetic suggestion for the formation of diisocyanoadociane reported from the same sponge.

Published
1980

10. Two polyhalogenated monoterpenes from the red alga

Author

Ronald J. Quinn, J.S. F-Konzern, Rymantas Kazlauskas, P. Schönhlzer, Peter T. Murphy, F.Hoffmann-La Roche, and Robert J. Wells

Subjects
biology, Chemistry, Organic Chemistry, Drug Discovery, Botany, biology.organism_classification, Biochemistry, Plocamium
Published
1976

13. Hippurin-1, an unusual steroid from the gorginian Isis hippuris

Author

Robert J. Wells, Ronald J. Quinn, Rymantas Kazlauskas, Peter T. Murphy, and Peter Schönholzer

Subjects
biology, Chemistry, medicine.medical_treatment, Isis hippuris, Organic Chemistry, Drug Discovery, medicine, Pharmacology, biology.organism_classification, Biochemistry, Steroid
Published
1977

14. A new sesquiterpene from the sponge

Author

Rymantas Kazlauskas, Peter T. Murphy, and Robert J. Wells

Subjects
chemistry.chemical_compound, Sponge, chemistry, biology, Organic Chemistry, Drug Discovery, Organic chemistry, Sesquiterpene, biology.organism_classification, Biochemistry
Published
1978

15. Two new sesterterpene lactones from a sponge

Author

Ronald J. Quinn, Rymantas Kazlauskas, Robert J. Wells, and Peter T. Murphy

Subjects
Sponge, biology, Chemistry, Organic Chemistry, Drug Discovery, Organic chemistry, biology.organism_classification, Biochemistry
Published
1976

17. Taonianone, a new diterpene from the brown alga

Author

Robert J. Wells, Peter T. Murphy, and Gregory March

Subjects
chemistry.chemical_compound, chemistry, Stereochemistry, Organic Chemistry, Drug Discovery, Diterpene, Ring (chemistry), Biochemistry
Abstract

Taonianone, a diterpene with a novel carbocyclic ring system has been isolated from the brown alga Taonia australasica .

Published
1981

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