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1. The preparation of N-alkyl-2(1H)-pyridones by ther reaction of amines with a derivative of 3-(2-pyridyl)propane-1,2-diol

Author

Michael H. Block

Subjects
chemistry.chemical_classification, Organic Chemistry, Diol, Alcohol, Biochemistry, Medicinal chemistry, chemistry.chemical_compound, chemistry, Propane, Yield (chemistry), Drug Discovery, Lactam, Organic chemistry, Derivative (chemistry), Alkyl, Amination
Abstract

The reduction of the 2-pyridyl orhtoester derivative 7 with DIBAL gives exclusively the secondary alcohol 9 in excellent yield. Mesylation of 9 followed by reaction with amines gives the unusual N -alkyl-2(1 H )-pyridones 11 and 12.

Published
1992
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