Search

Your search keyword '"Marakovits, Joseph"' showing total 2 results
Start Over Author "Marakovits, Joseph" Journal tetrahedron letters
2 results on '"Marakovits, Joseph"'

1. A novel method to enable SNAr reaction of aminopyrrolopyrazoles

Author

Marakovits Joseph T, Kephart Susan Elizabeth, Chuangxing Guo, and Dong Liming

Subjects
Reaction conditions, Nucleophilic aromatic substitution, Chemistry, Organic Chemistry, Drug Discovery, Organic chemistry, macromolecular substances, Weakly-reactive, Biochemistry, Combinatorial chemistry
Abstract

Here we report mild, environmentally-friendly reaction conditions which enable the addition–elimination S N Ar reaction between weakly reactive substrates––an aminopyrrolopyrazole template and several substituted pyrimidines. The method was developed during our efforts to synthesize a series of novel P21-activated kinase (PAK) inhibitors.

Published
2011
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results