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5 results on '"Jiejun, Wu"'

1. Carboxylation reaction of a highly functionalized vinylic anion: a case of unexpected stability and reactivity

Author

Neelakandha S. Mani, Sudip Basu, Josef Moravek, Laurent Gomez, Jiejun Wu, and J. Guy Breitenbucher

Subjects
chemistry.chemical_compound, chemistry, Carboxylation, Organic Chemistry, Drug Discovery, Organic chemistry, Reactivity (chemistry), Pyrazole, Cck1 receptor, Biochemistry, Combinatorial chemistry, Ion
Abstract

Attempts to prepare JNJ 26273364, a highly functionalized pyrazole-based CCK1 receptor antagonist, using a carboxylation reaction led to a series of unexpected results. This work demonstrated the unique reactivity and stability of the highly functionalized Z-alkene functionality present around the pyrazole.

Published
2010
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2. Pseudoenzymatic catalyst–substrate interactions in ion-pair mediated chiral phase transfer catalysis

Author

Thomas Ramirez, Robert Erik Plata, Apurba Bhattacharya, Tomas Vasques, and Jiejun Wu

Subjects
inorganic chemicals, biology, Chemistry, organic chemicals, Organic Chemistry, Substrate (chemistry), Cinchona, Chiral phase, Ion pairs, Photochemistry, biology.organism_classification, Biochemistry, Catalysis, Drug Discovery, Electronic effect, heterocyclic compounds
Abstract

Complementary electronic effects between the substrate and the cinchona-based catalyst in the pseudoenzymatic ion-pair mediated chiral phase transfer alkylations of indanone enolate anions were demonstrated.

Published
2006
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3. Eco-friendly reductive acetamidation of arylnitro compounds by thioacetate anion through in situ catalytic regeneration: application in the synthesis of Acetaminophen™

Author

Victor Suarez, Jiejun Wu, Apurba Bhattacharya, and Victoriano Tamez

Subjects
In situ, chemistry.chemical_compound, Chemistry, Regeneration (biology), Organic Chemistry, Drug Discovery, Organic chemistry, Thioacetic acid, Biochemistry, Environmentally friendly, Catalysis
Abstract

A novel one-step reductive acetamidation of arylnitro compounds mediated by thioacetate anion in thioacetic acid via in situ catalytic regeneration was developed and applied to an efficient synthesis of Acetaminophen™.

Published
2006
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4. Surfactant-mediated solvent-free dealkylative cleavage of ethers and esters and trans-alkylation under neutral conditions

Author

Nitin C. Patel, Ritesh Tichkule, Tomas Vasques, Gaurang Parmar, Jiejun Wu, and Apurba Bhattacharya

Subjects
chemistry.chemical_compound, Solvent free, Pulmonary surfactant, Chemistry, Aryl, Organic Chemistry, Drug Discovery, Polymer chemistry, Organic chemistry, Cleavage (crystal), General Medicine, Alkylation, Biochemistry
Abstract

A simple, surfactant-mediated, one-pot, solvent-free dealkylative cleavage of aryl ethers and esters followed by subsequent optional trans-alkylation under essentially neutral conditions has been developed.

Published
2006
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5. An efficient conversion of nitriles to amides: application in the synthesis of N,N-diethyl-m-toluamide (DEET™)

Author

Jiejun Wu, Savitha Muramulla, Apurba Bhattacharya, Robert Erik Plata, and Victor Villarreal

Subjects
animal structures, Magnesium, education, fungi, Organic Chemistry, chemistry.chemical_element, Biochemistry, humanities, DEET, chemistry.chemical_compound, chemistry, Yield (chemistry), Drug Discovery, Organic chemistry, Insect repellent
Abstract

Arylnitriles react with magnesium amides to produce carboxamides in excellent yield. The method was applied for the preparation of the insect repellent DEET™.

Published
2006
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