1. (+)- and (−)-Eurotone A: A pair of enantiomeric polyketide dimers from a marine-derived fungus Eurotium sp. SCSIO F452
- Author
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Xin-Peng Tian, Yao Xiang, Junfeng Wang, Lijuan Long, Fa-Zuo Wang, Xiaoyi Wei, Si Zhang, Weimao Zhong, Xia-Yu Chen, and Qi Zeng
- Subjects
Quantum chemical ,biology ,010405 organic chemistry ,Chemistry ,Stereochemistry ,Organic Chemistry ,Fungus ,010402 general chemistry ,biology.organism_classification ,01 natural sciences ,Biochemistry ,0104 chemical sciences ,Eurotium sp. SCSIO F452 ,Polyketide ,Drug Discovery ,Enantiomer ,Marine fungi - Abstract
(±)-Eurotone A [(±)- 1 ], a pair of new enantiomeric polyketide dimers, as well as six known biogenetically related polyketides ( 2 – 7 ) were isolated from a marine-derived fungus Eurotium sp. SCSIO F452. Their structures were determined by comprehensive spectroscopic methods, X-ray diffraction and quantum chemical calculations. Compound 1 represented the first pair of spirodihydrobenzanthracene enantiomers isolated from marine fungi with their absolute configurations assigned. A plausible biosynthetic pathway involving a key acid-mediated dimerization was proposed for 1 . The antioxidative activities of the new enantiomers were evaluated.
- Published
- 2019