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Your search keyword '"1,4-Cyclohexadiene"' showing total 10 results
Start Over Descriptor "1,4-Cyclohexadiene" Journal tetrahedron letters
10 results on '"1,4-Cyclohexadiene"'

1. 1,4-Cyclohexadiene with Pd/C as a rapid, safe transfer hydrogenation system with microwave heating

Author

Brian T. Gregg, John F. Quinn, Kathryn C. Golden, and Dana A. Razzano

Subjects
Carboxybenzyl, Chemistry, Organic Chemistry, Inorganic chemistry, Hydrogen transfer, Transfer hydrogenation, Photochemistry, Biochemistry, Catalysis, chemistry.chemical_compound, Microwave heating, Palladium on carbon, Drug Discovery, 1,4-Cyclohexadiene, Microwave
Abstract

A method for the rapid, safe hydrogenation of alkenes and deprotection of benzyl ethers and carboxybenzyl amides is described using catalytic transfer hydrogenation under microwave heating conditions. Commonly available Pd/C catalyst is extremely effective with 1,4-cyclohexadiene as the hydrogen transfer source. In general, the reactions are complete within five minutes at 100 °C.

Published
2008

2. Sequential ring-opening of trans-1,4-cyclohexadiene dioxide for an expedient modular approach to 6,7-disubstituted (±)-hexahydro-benzo[1,4]oxazin-3-ones

Author

Dietlind Sorger, Osama Sabri, Elena Kouznetsova, Jörg Steinbach, Reinhard Schliebs, Matthias Scheunemann, and Barbara Wenzel

Subjects
Stereochemistry, business.industry, Organic Chemistry, General Medicine, Modular design, Ring (chemistry), Biochemistry, Medicinal chemistry, chemistry.chemical_compound, Benzylamine, chemistry, Nucleophile, Drug Discovery, Electrophile, 1,4-Cyclohexadiene, business
Abstract

A modular approach to novel 6-amino-7-hydroxysubstituted hexahydro-benzo[1,4]oxazin-3-ones has been developed. The method involves a sequential ring-opening of trans-1,4-cyclohexadiene dioxide with amino nucleophiles. The resultant mono-epoxide from benzylamine was converted to a general electrophilic precursor, which enables the parallel treatment with amino nucleophiles to obtain a series of cyclohexane-fused morpholin-3-ones.

Published
2007

3. Lewis acid-catalyzed reduction of dithioacetals by 1,4-cyclohexadiene

Author

Kei-ichiro Ikeshita, Akiya Ogawa, Nobuhiro Kihara, and Motohiro Sonoda

Subjects
Reduction (complexity), chemistry.chemical_compound, Chemistry, Organic Chemistry, Drug Discovery, Lewis acids and bases, 1,4-Cyclohexadiene, Biochemistry, Medicinal chemistry, Catalysis
Abstract

Dithioacetals were reduced by 1,4-cyclohexadiene in the presence of a catalytic amount of Lewis acid to afford the corresponding sulfides in good yields.

Published
2007

4. An unusual base induced 1,5-electrocyclization of a tetracyclic 1,4-cyclohexadiene derivative

Author

Thierry Prangé, Valérie Blanchot-Courtois, and Issam Hanna

Subjects
chemistry.chemical_classification, chemistry.chemical_compound, Electrocyclic reaction, Base (chemistry), Chemistry, Stereochemistry, Organic Chemistry, Drug Discovery, Molecule, Crystal structure, 1,4-Cyclohexadiene, Biochemistry, Derivative (chemistry)
Abstract

Treatment of tetracyclic 1,4-cyclohexadiene 1 with LDA in THF at −70°C led to 2 by an unusual 1,5-electrocyclization; the structure of 2 was established by spectroscopic data and by X-ray crystallographic analysis.

Published
1992

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