1. Stereoselective synthesis of a C1−C18 fragment of amphidinolides G and H
- Author
-
García-Fortanet, Jorge, Formentín, Pilar, Díaz-Oltra, Santiago, Murga, Juan, Carda, Miguel, and Alberto Marco, J.
- Subjects
- *
STEREOSELECTIVE reactions , *MACROLIDE antibiotics , *OLEFINATION reactions , *CHIRALITY , *MOLECULAR structure , *COUPLING reactions (Chemistry) , *ORGANIC synthesis - Abstract
Abstract: A stereoselective synthesis of a C1–C18 segment of the structure of the cytotoxic macrolides amphidinolides G and H is reported. The target compound was retrosynthetically disconnected into three fragments. In the synthetic sense, connection of the fragments was made by means of a Stille coupling and a Julia–Kocienski olefination. Precursors from the chiral pool were used as the starting materials. [Copyright &y& Elsevier]
- Published
- 2013
- Full Text
- View/download PDF