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2 results on '"Romeo Ciabatti"'

1. Chemical modification of the GE 2270A macrocycle (MDL 62,879)

Author

Riccardo Bonfichi, Romeo Ciabatti, Paolo Tavecchia, Sergio Lociuro, Luigi Colombo, Michael Kurz, Ettore Marzorati, and Enrico Selva

Subjects
chemistry.chemical_compound, Selective opening, chemistry, Organic Chemistry, Drug Discovery, Organic chemistry, Chemical modification, Acid hydrolysis, Thiazole, Biochemistry
Abstract

Controlled acid hydrolysis of compound 2 resulted in the selective opening of the macrocycle while in basic condition a retro-aldol reaction occurred at the level of phenylserine thiazole. Compound 2 can be easily prepared from the natural antibiotic MDL 62,879. All the compounds prepared resulted less active than MDL 62,879.

Published
1996
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2. Degradation studies of antibiotic MDL 62,879 (GE2270A) and revision of the structure

Author

Sergio Lociuro, Romeo Ciabatti, Riccardo Bonfichi, Paolo Tavecchia, Enrico Selva, Ermenegildo Restelli, Michael Kurz, Cristina Sottani, and Patrizia Gentili

Subjects
chemistry.chemical_classification, chemistry, Stereochemistry, medicine.drug_class, Organic Chemistry, Drug Discovery, Antibiotics, medicine, Degradation (geology), Biochemistry, Combinatorial chemistry, Amino acid, Stereocenter
Abstract

Fragments of the thiopeptide antibiotic MDL 62,879 (GE2270A) were prepared under mild degradation conditions. Their structures were determined by spectroscopic techniques and by comparison to synthetic reference thiazolyl dipeptides. The two thiazolyl amino acids have stereocenters with S configurations and their sequence is reversed with respect to the structure previously proposed for MDL 62,879.

Published
1995
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