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It has been found that Snyder's eluant strength parameter e°, used in liquid-solid adsorption chromatography, can be well described by a complementary Lewis acid-base model for solute-solvent interactions: e°=0.152+0.859 · E N T + 0.332 · B KT ( cf Eq.9 ), with a correlation coefficient of r = 0.949 for 28 solvents. This result is in agreement with the theoretical interpretation of e° The correct statistical procedure for estimating the significance of added explanatory parameters in the sequential multiparameter regression analysis is shown ( cf Appendix). A comprehensive list of improved Kamlet-Taft solvent basicity parameters, B KT , is given.

Empirical parameters of Lewis acidity, E N T , introduced by Reichardt et al., and Lewis basicity, B KT , introduced by Kamlet and Taft, have been determined for mixtures of water with ten organic solvents. In the case of water/alcohol mixtures a distinct dependence between these acidity and basicity parameters have been found. For the other solvent mixtures the E N T on B KT dependence is more complex even if these parameters are purified from non-specific solute/solvent interactions.