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Start Over Descriptor "NOBIN" Journal tetrahedron
2 results on '"NOBIN"'

1. Highly stereoselective direct aldol reactions catalyzed by (S)-NOBIN-l-prolinamide

Author

Russo, Alessio, Botta, Giovanna, and Lattanzi, Alessandra

Subjects
*PROLINE, *AMIDES, *KETONES, *CHEMICAL reactions
Abstract

Abstract: (S)-NOBIN-l-prolinamide was employed as organocatalyst in the direct aldol reactions of different ketones and aromatic aldehydes using dioxane as solvent and in the presence of water as additive. Acetone led to the aldol products in up to 93% ee, while cyclic ketones furnished the anti-aldols in moderate to high yield, excellent diastereoselectivity (up to >99/<1 anti/syn ratio) and high ee (up to 95%). [Copyright &y& Elsevier]

Published
2007
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2. Asymmetric hetero-Diels–Alder reactions of carbonyl compounds

Author

Hélène Pellissier

Subjects
chemistry.chemical_classification, Chiral auxiliary, Organic Chemistry, Enantioselective synthesis, Thio, Biochemistry, Aldehyde, Catalysis, chemistry.chemical_compound, chemistry, NOBIN, Drug Discovery, Organic chemistry, Enone, BINAP
Abstract

This review is intended to update the most recent developments in asymmetric hetero-Diels–Alder (HDA) reactions of carbonyl compounds, covering the literature from 2000 to 2008. The reactions of unactivated aldehydes, activated aldehydes, activated ketones and the inverse HDA reactions of α,β-unsaturated ketones and α,β-unsaturated aldehydes are successively investigated. This review clearly demonstrates the power of asymmetric HDA reactions of carbonyl compounds for the construction of chiral six-membered oxygen-containing heterocycles, with extensive synthetic applications in natural or unnatural products with a wide range of biological activity. Figure options Download full-size image Download as PowerPoint slide

Published
2009
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