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3 results on '"Fei-Long Li"'

1. Palladium-catalyzed decarboxylative C3-acylation of benzofurans and benzothiophenes with α-oxocarboxylic acids via direct sp2 C–H bond activation

Author

Fei-Long Li, Jun Gao, De-Xian Liu, Jian-Ping Lang, Hong-Xi Li, and Wei-Jie Gong

Subjects
C h bond, Chemistry, Decarboxylation, Organic Chemistry, Benzothiophene, chemistry.chemical_element, Biochemistry, Medicinal chemistry, Catalysis, Acylation, chemistry.chemical_compound, Drug Discovery, Benzofuran, Palladium
Abstract

An efficient approach to decarboxylative C3-acylation of benzothiophenes or benzofurans with α-oxocarboxylic acids via palladium-catalyzed C–H bond activation was developed. This method was compatible with a variety of functional groups and provided an attractive route to 3-acylbenzothiophenes and 3-acylbenzofurans in good to high yields.

Published
2015

2. Palladium(II)-catalyzed Suzuki–Miyaura reactions of arylboronic acid with aryl halide in water in the presence of 4-(benzylthio)-N,N,N-trimethybenzenammonium chloride

Author

Jian-Ping Lang, De-Xian Liu, Jun Gao, Wei-Jie Gong, Hong-Xi Li, and Fei-Long Li

Subjects
chemistry.chemical_classification, Aqueous medium, Aryl, Aryl halide, Organic Chemistry, chemistry.chemical_element, Biochemistry, Chloride, Medicinal chemistry, Coupling reaction, Catalysis, chemistry.chemical_compound, chemistry, Bromide, Drug Discovery, medicine, medicine.drug, Palladium
Abstract

This work reported that Suzuki–Miyaura coupling reactions of arylboronic acid with aryl bromide or iodides were mediated by Pd(OAc)2 and 4-(benzylthio)-N,N,N-trimethylbenzenammonium chloride in the presence of Na2CO3 in water under the mild conditions. The corresponding Suzuki–Miyaura coupling products were obtained in good to excellent yields.

Published
2014

3. Synthesis of 1,4-diarylsubstituted 1,3-diynes through ligand-free copper-catalyzed oxidative decarboxylative homocoupling of aryl propiolic acids

Author

De-Xian Liu, Jian-Ping Lang, Jun Gao, Hong-Xi Li, and Fei-Long Li

Subjects
Steric effects, Ligand, Aryl, Organic Chemistry, Oxidative phosphorylation, Bond formation, Biochemistry, Medicinal chemistry, Catalysis, chemistry.chemical_compound, chemistry, Drug Discovery, Copper catalyzed, Organic chemistry
Abstract

An efficient method of ligand-free Cu-catalyzed oxidative decarboxylative homocoupling of aryl propiolic acids was developed. When CuI was employed as the catalyst and I 2 as the oxidant, the decarboxylative homocoupling reaction for C sp –C sp bond formation in DMSO underwent smoothly to afford the corresponding 1,4-disubstituted 1,3-dialkynes in good to excellent yields without any organic ligands. This catalytic system was applicable to aryl propiolic acids bearing different steric, electronic, and functional groups.

Published
2014

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