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Enhanced intestinal permeability is a pervasive issue in modern medicine, with implications demonstrably associated with significant health consequences such as sepsis, multiorgan failure, and death. Key issues involve the trigger mechanisms that could compromise intestinal integrity and increase local permeability allowing the passage of larger, potentially dangerous molecules. Heat stress, whether exertional or environmental, may modulate intestinal permeability and begs interesting questions in the context of global climate change, increasing population vulnerabilities, and public health. Emerging evidence indicates that intestinal leakage of digestive enzymes and associated cell dysfunctions--a process referred to as autodigestion--may play a critical role in systemic physiological damage within the body. This increased permeability is exacerbated in the presence of elevated core temperatures. We employed Latent Dirichlet Allocation (LDA) topic modeling methods to analyze the relationship between heat stress and the nascent theory of autodigestion in a systematic, quantifiable, and unbiased manner. From a corpus of 11,233 scientific articles across four relevant scientific journals (Gut, Shock, Temperature, Gastroenterology), it was found that over 1,000 documents expressed a relationship between intestine, enhanced permeability, core temperature, and heat stress. The association has grown stronger in recent years, as heat stress and potential autodigestion are investigated in tandem, yet still by a limited number of specific research studies. Such findings justify the design of future studies to critically test novel interventions against digestive enzymes permeating the intestinal tract, especially the small intestine.

Fine-scale personal heat exposure (PHE) information can help prevent or minimize weather-related deaths, illnesses, and reduced work productivity. Common methods to estimate heat risk do not simultaneously account for the intensity, frequency, and duration of thermal exposures, nor do they include inter-individual factors that modify physiological response. This study demonstrates new whole-body net thermal load estimations to link PHE to heat stress and strain over time. We apply a human-environment heat exchange model to examine how time-varying net thermal loads differ across climate contexts, personal attributes, and spatiotemporal scales. First, we investigate summertime climatic PHE impacts for three US cities: Phoenix, Miami, and New York. Second, we model body morphology and acclimatization for three profiles (middle-aged male/female; female >65 years). Finally, we quantify model sensitivity using representative data at synoptic and micro-scales. For all cases, we compare required and potential evaporative heat losses that can lead to dangerous thermal exposures based on (un)compensable heat stress. Results reveal misclassifications in heat stress or strain due to incomplete environmental data and assumed equivalent physiology and activities between people. Heat strain is most poorly represented by PHE alone for the elderly, non-acclimatized, those engaged in strenuous activities, and when negating solar radiation. Moreover, humid versus dry heat across climates elicits distinct thermal responses from the body. We outline criteria for inclusive PHE evaluations connecting heat exposure, stress, and strain while using physiological-based methods to avoid misclassifications. This work underlines the value of moving from "one-size-fits-all" thermal indices to "fit-for-purpose" approaches using personalized information. [ABSTRACT FROM AUTHOR]

Personal solar ultraviolet radiation exposure models were developed for 144 Olympic events scheduled outdoors from across the 33 sport disciplines that will compete in Tokyo between 24 July and 9 August 2020. Ambient exposure models were developed from existing atmospheric parameters measured over Tokyo (35.7°N 139.7°E) and were used to weight erythemally effective solar ultraviolet exposure to gold medalists, taking into account body posture and expected protection by competitor's clothing which was assessed in comparison to respective medalists of the 2016 Rio Olympics. Individual exposure models consider the ultraviolet surface albedo (lawn, concrete, water or sand) and timing of daily events held within Olympic venues. Exposure assessments are presented, including assessments of all preliminary rounds and qualifiers. Within scheduled outdoor events, we award first place (representing the highest and most harmful UV exposure) to the women's tennis singles (1680 J/m2), second to men's golf (1530 J/m2) and third to the men's cycling road race (941 J/m2) for the highest expected erythemally effective solar ultraviolet radiation exposures of the 2020 Tokyo Games. The highest expected solar ultraviolet exposures for nations expected to win greater than three gold medals among the outdoor events were found to occur in athletes from Kenya followed closely by the United States and Hungary. Gold medalists from South Korea were found to demonstrate the highest level of sun protection due to clothing at the 2016 Rio Games, and are thus expected to receive the greatest relative reduction in erythemally effective exposure during the 2020 Tokyo Games. [ABSTRACT FROM AUTHOR]