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Internet-based computer information systems play critical roles in many aspects of modern society. However, these systems are constantly under cyber attacks that can cause catastrophic consequences. To defend these systems effectively, it is necessary to measure and predict the effectiveness of cyber defense mechanisms. In this article, we investigate how to measure and predict the effectiveness of an important cyber defense mechanism that is known as early-warning. This turns out to be a challenging problem because we must accommodate the dependence among certain four-dimensional time series. In the course of using a dataset to demonstrate the prediction methodology, we discovered a new nonexchangeable and rotationally symmetric dependence structure, which may be of independent value. We propose a new vine copula model to accommodate the newly discovered dependence structure, and show that the new model can predict the effectiveness of early-warning more accurately than the others. We also discus...