After almost 40 years of the discovery and successful culture of the Helicobacter pylori, scientists are facing its resistance strategies that have challenged the world of biomedicine. Nanotechnology, on the other hand, has come to the aid of developing more efficient strategies against this bacterium in the arms race that we are involved in. Metallic nanoparticles with their fascinating properties, such as magnetism, ease of synthesis, biocompatibility, and wide range of sizes and shapes, have attracted lots of attention. The present review provides crucial information on these nanoparticles and the possible ways of their use for the eradication of H. pylori.