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2. Enantioselective extraction of (+)-(S)-citalopram and its main metabolites using a tailor-made stir bar chiral imprinted polymer for their LC-ESI-MS/MS quantitation in urine samples.

Author

Unceta N, Gómez-Caballero A, García D, Díaz G, Guerreiro A, Piletsky S, Goicolea MA, and Barrio RJ

Subjects
Adsorption, Chromatography, Liquid, Humans, Molecular Imprinting methods, Reference Standards, Sensitivity and Specificity, Solid Phase Extraction methods, Spectrometry, Mass, Electrospray Ionization, Stereoisomerism, Tandem Mass Spectrometry, Antidepressive Agents, Second-Generation urine, Citalopram analogs & derivatives, Citalopram urine, Polymers chemistry, Solid Phase Extraction standards
Abstract

This paper reports the application of a chiral imprinted polymer (CIP)-coated stir bar for the selective extraction of (+)-(S)-citalopram (SCIT) and its main metabolites, (+)-(S)-desmethylcitalopram (SDCIT) and (+)-(S)-didesmethylcitalopram (SDDCIT), from urine samples. The developed device has been demonstrated to be capable of selectively extracting the three target analytes from urine samples without saturating the imprinted sites. A CIP-coated stir bar sorptive extraction procedure (CIP-SBSE) is proposed for the isolation of SCIT, SDCIT and SDDCIT followed by their subsequent analysis using liquid chromatography ion trap mass spectrometry (LC-ITMS). Deuterated SCIT-d6 was used as an internal standard. The method was validated using a standard procedure, which revealed that a quantification of 5 ng mL(-1) was obtained in urine samples and that the accuracy and precision were within the established values while no matrix effect was observed., (Copyright © 2013 Elsevier B.V. All rights reserved.)

Published
2013
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