1. Synthesis and evaluation of the anticancer activity of some semisynthetic derivatives of rutaecarpine and evodiamine.
- Author
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Patrykei, Serhii, Korobko, Yulia, Ogorodniichuk, Oleksandr, Garazd, Myroslav, Polishchuk, Pavel, Džubák, Petr, Gurská, Soňa, Hajdúch, Marián, and Lesyk, Roman
- Subjects
ANTINEOPLASTIC agents ,MYELOID leukemia ,ELEMENTAL analysis ,QUINAZOLINE ,LUNG cancer - Abstract
The synthesis and anticancer activity evaluation of new quinazoline alkaloids rutaecarpine and evodiamine semisynthetic derivatives and their molecular hybrids with lupinine moiety is described. Newly synthesized compounds were elucidated based on elemental analyses and spectral data (
1 H and13 C NMR). Anticancer cytotoxicity was studied toward some cell lines of lung cancer, T-lymphoblastic leukemia, colon cancer, myeloid leukemia, and osteosarcoma. Among the tested compounds, the highest activity with a specific sensitivity profile toward the Leukemia cell lines CCRF-CEM and K-562 was demonstrated by the starting compound evodiamine. Structural modifications of the studied quinazoline alkaloids did not lead to the improvement of anticancer activity. [ABSTRACT FROM AUTHOR]- Published
- 2021
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