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This article presents a method for synthesizing 6,6-Dimethyl-3-oxabicyclo [3.1.0]hexan-2-one, an important compound used in the production of pharmaceutical ingredients like Nirmatrelvir. The authors discuss different approaches to synthesizing this compound and propose their own efficient and scalable method involving an organocatalyzed desymmetrization step and a chemoselective reduction. They provide detailed procedures and reaction conditions for each step, along with NMR data and acknowledgments. The synthesis yields the desired compound in good yield and high purity. [Extracted from the article]