1. Asymmetric Total Synthesis of (+)-Coprophilin
- Author
-
Takayuki Tonoi, Takatsugu Murata, Isamu Shiina, Yuma Umezaki, and Kyohei Suzuki
- Subjects
0301 basic medicine ,03 medical and health sciences ,030102 biochemistry & molecular biology ,Aldol reaction ,Chemistry ,Intramolecular force ,Organic Chemistry ,Total synthesis ,Stereoselectivity ,Coprophilin ,Combinatorial chemistry ,Catalysis ,Diels–Alder reaction - Abstract
In this paper, we report the first total synthesis of (+)-coprophilin, an anticoccidial agent, by constructing the chiral linear precursor via a Mukaiyama–Evans aldol reaction and a stereoselective intramolecular Diels–Alder reaction. The proposed method can be used to provide large amounts of (+)-coprophilin, which exhibits a 3,4,5,6,7-pentasubstituted Δ1,2-octalin core structure.
- Published
- 2017
- Full Text
- View/download PDF