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This article discusses the synthesis of cryptocaryolone, a compound found in the plant genus Cryptocarya, which has various biological activities and medical properties. The authors describe a novel strategy using Prins cyclization to construct the bicyclic lactone core of cryptocaryolone in a single step. They outline the synthetic approach and provide detailed experimental procedures for the preparation of the starting materials and the cyclization reaction. The method is highly diastereoselective and yields the desired product with a single diastereomer. The article also includes information about the reaction conditions, purification methods, and characterization of the synthesized compounds, as well as the optical rotation, infrared spectroscopy, and nuclear magnetic resonance data for each compound. The authors acknowledge funding support from CSIR, New Delhi. [Extracted from the article]