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1. Practical Synthesis of Fluorinated Piperidine Analogues Based on the 2-Azaspiro[3.3]heptane Scaffold

Author

Anton N. Tkachenko, Anton V. Chernykh, Dmitriy M. Volochnyuk, Illia O. Feskov, Dmytro S. Radchenko, Nataliya A. Tolmachova, and Constantin G. Daniliuc

Subjects
Heptane, chemistry.chemical_compound, Scaffold, chemistry, 010405 organic chemistry, Organic Chemistry, Organic chemistry, Piperidine, 010402 general chemistry, 01 natural sciences, 0104 chemical sciences
Abstract

The synthesis of a set of conformationally restricted fluorinated analogues of piperidine, based on a 2-azaspiro[3.3]heptane scaffold, is reported. Different pattern of fluorine substitution within the rigid skeleton make the analogues excellent candidates for use in drug design. The overall simplicity of the experimental procedures and the availability of inexpensive starting materials allow for multigram-scale syntheses of the described compounds.

Published
2016
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