Search

Your search keyword '"Jessica Giacoboni"' showing total 2 results
Start Over Author "Jessica Giacoboni" Journal synlett
2 results on '"Jessica Giacoboni"'

1. Novel Approach toward 3,3-Difluoropiperidines from Easily Available Starting Materials and Synthesis of a New Phosphodiesterase Inhibitor

Author

Rasmus P. Clausen, Mauro Marigo, and Jessica Giacoboni

Subjects
chemistry.chemical_compound, 010405 organic chemistry, Chemistry, Organic Chemistry, Phosphodiesterase, Organic chemistry, Piperidine, Phosphodiesterase inhibitor, 010402 general chemistry, 01 natural sciences, Reductive amination, 0104 chemical sciences
Abstract

A novel methodology for the synthesis of 3,3-difluoropiperidines has been developed. The target compounds are prepared in three steps using a robust protocol and simple starting materials. The incorporation of the fluorine is achieved by using the cheap and easily available ethyl 2-bromo-2,2-difluoroacetate as building block. Using this methodology, a new potent in vitro phosphodiesterase 2A (PDE2A) inhibitor containing the functionalized fluorinated piperidine scaffold has been prepared.

Published
2016

2. A Highly Stereoselective Organocatalytic Approach to Lilial® and Muguesia

Author

Pier Giorgio Cozzi, Marco Giuseppe Emma, Luca Mengozzi, Jessica Giacoboni, Andrea Gualandi, A. Gualandi, M. G. Emma, J. Giacoboni, L. Mengozzi, and P. G. Cozzi

Subjects
MACMILLAN CATALYSTS, ORGANOCATALYSIS, Organic Chemistry, Alkylation, Enamine, ENAMINE, chemistry.chemical_compound, chemistry, Organocatalysis, Organic chemistry, ALKYLATIONS, Stereoselectivity, Lilial, ALDEHYDES
Abstract

The stereoselective alkylation of aldehydes with benzodithiolylium tetrafluoborate gave a straightforward access to key compounds for the synthesis of fragrances and flavors.

Published
2013

Catalog

Books, media, physical & digital resources
See catalog results