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2. α-Metalated Isocyanides Toward a Tangible Reagent Space.

Author

Fragkiadakis, Michael and Neochoritis, Constantinos G.

Subjects
*ISOCYANIDES, *OXAZOLES, *ANHYDRIDES, *FUNCTIONAL groups, *LACTONES, *RING-opening polymerization
Abstract

α-Metalated isocyanides are a versatile class of compounds that can easily be employed in various transformations, affording tangible libraries for screening campaigns. We report the ring-opening reactions of cyclic anhydrides and lactones with three different metalated isocyanides that readily give 4,5-disubstituted oxazoles, including useful drug-like synthetic intermediates with two functional groups as handles for further modifications. [ABSTRACT FROM AUTHOR]

Published
2022
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