Author: "Clarke, Matthew L." / Journal: synlett / Publication Year Range: Last 50 years / Search Limiters: Peer Reviewed / Topic: asymmetric synthesis - Searchworks@Jio Institute Digital Library Search Results

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Start Over Author "Clarke, Matthew L." Search Limiters Peer Reviewed Topic asymmetric synthesis Publication Year Range Last 50 years Journal synlett

Author: Clarke, Matthew L., France, Marcia B., Knight, Fergus R., Frew, Jamie J., and Roff, Geoffrey J.
Subjects: *KETONE synthesis, *DIBENZOYLMETHANE, *HYDROGENATION kinetics, *DIPHOSPHINE, *ASYMMETRIC synthesis
Abstract: Asymmetric hydrogenation of dibenzoyl-difluoro�methane has been studied for the first time. In contrast to �BINAL-H, baker’s yeast and CBS reduction procedures, ruthenium-catalysed hydrogenation using axially chiral diphosphine ligands provides excellent yield, diastereoselectivity and good enantioselectivity (up to 72% ee). Enantiomer enrichment by recrystallisation allows for the pure fluorinated diol to be isolated as a single enantiomer in moderate yield. [ABSTRACT FROM AUTHOR]
Published: 2007
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