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Bent Laue monochromator HEX is designed with a high-energy non-focusing X-ray monochromator for full-field imaging. The following design ideas apply to the imaging monochromator: The HEX center branch, which the monochromator serves, is white-beam compatible. The monochromator is located in the first optical enclosure with the following parameters: source to monochromator distance is 31 m; monochromator to sample distance is 73 m. Diffraction Enhanced Imaging (DEI) or Analyzer Based Imaging (ABI) uses a perfect crystal monochromator and matching analyzer to achieve sensitivity to X-ray refraction and ultra small-angle scattering on the order of 0.01 micro-radians. [Extracted from the article]

Diffraction enhanced imaging (DEI), also called analyzer-based imaging (ABI), cultivated within the synchrotron community, has the potential to revolutionize medical imaging through reduced dose and enhanced contrast imaging. [ABSTRACT FROM AUTHOR]

We explored diffraction enhanced imaging (DEI) in both planar and computed tomography (CT) modes for early detection of beta amyloid deposition, a hallmark feature in Alzheimer's disease (AD). Since amyloid plaques precede clinical symptoms by years, their early detection is of great interest. These findings were correlated with results from synchrotron infrared microspectroscopic imaging and X-ray fluorescence microscopy, to determine the secondary structure of the amyloid beta protein and metal concentration in the amyloid plaques, respectively. [ABSTRACT FROM AUTHOR]

The article focuses on the instrumentation, mechanism and applicability of Diffraction Enhanced Imaging (DEI) in soft tissue imaging. It offers brief information on principles and concepts of DEI including the preparation of an imaging beam, the refraction and extinction as two sources of image contrast to radiography, and the stages of scanning. It also explores the DEI imaging in breast, cartilage, and lungs.