1. CART peptides in the central control of feeding and interactions with neuropeptide Y
- Author
-
Michael J. Kuhar, Kathleen M McGirr, Yoland Smith, Pastor R. Couceyro, Stephanie Dall Vechia, and Philip D. Lambert
- Subjects
chemistry.chemical_classification ,Cart ,medicine.medical_specialty ,virus diseases ,Endogeny ,Peptide ,Biology ,Neuropeptide Y receptor ,Inhibitory postsynaptic potential ,Cocaine and amphetamine regulated transcript ,Synapse ,Cellular and Molecular Neuroscience ,Endocrinology ,nervous system ,chemistry ,immune system diseases ,Hypothalamus ,Internal medicine ,mental disorders ,medicine ,hormones, hormone substitutes, and hormone antagonists - Abstract
While CART peptides have been implicated as novel, putative peptide neurotransmitters/cotransmitters, behavioral effects of these peptides have not yet been demonstrated. In this study, we show the first behavioral effect of CART peptides. Icv administration of CART peptide fragments inhibits feeding in rats. Moreover, injection of an antibody to CART peptide 82–103 stimulates feeding, suggesting that endogenous CART peptides exert an inhibitory tone on feeding. Injection of CART peptide 82–103 five min before NPY reduces the increase in feeding caused by injection of NPY alone. Also, in light microscopic immunohistochemical studies, NPY-positive varicosities were observed around CART peptide-positive cell bodies in the paraventricular nucleus of the hypothalamus. These data suggest functional interactions between CART peptides and NPY. These results indicate that CART peptides play a role in the control of food intake by the brain. Synapse 29:293–298, 1998. © 1998 Wiley-Liss, Inc.
- Published
- 1998