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8 results on '"Horiuchi, Hiroshi"'

1. Changes in the expression of IL-6-Mediated MicroRNAs in the dorsal root ganglion under neuropathic pain in mice

Author

Hori, Naosuke, primary, Narita, Michiko, additional, Yamashita, Akira, additional, Horiuchi, Hiroshi, additional, Hamada, Yusuke, additional, Kondo, Takashige, additional, Watanabe, Moe, additional, Igarashi, Katsuhide, additional, Kawata, Miho, additional, Shibasaki, Masahiro, additional, Yamazaki, Mitsuaki, additional, Kuzumaki, Naoko, additional, Inada, Eiichi, additional, Ochiya, Takahiro, additional, Iseki, Masako, additional, Mori, Tomohisa, additional, and Narita, Minoru, additional

Published
2016
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2. Effects of mirtazapine on sleep disturbance under neuropathic pain-like state

Author

Enomoto, Tatsuya, primary, Yamashita, Akira, additional, Torigoe, Kazuhiro, additional, Horiuchi, Hiroshi, additional, Hirayama, Shigeto, additional, Nakahara, Kae, additional, Yanase, Makoto, additional, Sakai, Hiroyasu, additional, Ikegami, Daigo, additional, Nagase, Hiroshi, additional, Suzuki, Tsutomu, additional, Iseki, Masako, additional, Inada, Eiichi, additional, and Narita, Minoru, additional

Published
2012
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5. Effects of gabapentin on brain hyperactivity related to pain and sleep disturbance under a neuropathic pain-like state using fMRI and brain wave analysis

Author

Takemura, Yoshinori, primary, Yamashita, Akira, additional, Horiuchi, Hiroshi, additional, Furuya, Masaharu, additional, Yanase, Makoto, additional, Niikura, Keiichi, additional, Imai, Satoshi, additional, Hatakeyama, Noboru, additional, Kinoshita, Hiroyuki, additional, Tsukiyama, Yoshi, additional, Senba, Emiko, additional, Matoba, Motohiro, additional, Kuzumaki, Naoko, additional, Yamazaki, Mitsuaki, additional, Suzuki, Tsutomu, additional, and Narita, Minoru, additional

Published
2011
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6. Enhancement of glutamatergic transmission in the cingulate cortex in response to mild noxious stimuli under a neuropathic pain‐like state

Author

Niikura, Keiichi, primary, Furuya, Masaharu, additional, Narita, Michiko, additional, Torigoe, Kazuhiro, additional, Kobayashi, Yasuhisa, additional, Takemura, Yoshinori, additional, Yamazaki, Mitsuaki, additional, Horiuchi, Hiroshi, additional, Enomoto, Tatsuya, additional, Iseki, Masako, additional, Kinoshita, Hiroyuki, additional, Tomiyasu, Shiro, additional, Imai, Satoshi, additional, Kuzumaki, Naoko, additional, Suzuki, Tsutomu, additional, and Narita, Minoru, additional

Published
2010
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7. Subdiaphragmatic vagotomy increases the sensitivity of lumbar Aδ primary afferent neurons along with voltage-dependent potassium channels in rats.

Author

Furuta, Sadayoshi, Watanabe, Lisa, Doi, Seira, Horiuchi, Hiroshi, Matsumoto, Kenjiro, Kuzumaki, Naoko, Suzuki, Tsutomu, and Narita, Minoru

Abstract

Subdiaphragmatic vagal dysfunction causes chronic pain. To verify whether this chronic pain is accompanied by enhanced peripheral nociceptive sensitivity, we evaluated primary afferent neuronal excitability in subdiaphragmatic vagotomized (SDV) rats. SDV rats showed a decrease in the electrical stimuli-induced hind limb-flexion threshold at 250 Hz, but showed no similar effect at 5 or 2000 Hz, which indicated that lumbar primary afferent Aδ sensitivity was enhanced in SDV rats. The whole-cell patch-clamp technique also revealed the hyper-excitability of acutely dissociated medium-sized lumbar dorsal root ganglion (DRG) neurons isolated from SDV rats. The contribution of changes in voltage-dependent potassium (Kv) channels was assessed, and transient A-type K+ ( IA) current density was apparently decreased. Moreover, Kv4.3 immunoreactivity in medium-sized DRG neurons was significantly reduced in SDV rats compared to sham. These results indicate that SDV causes hyper-excitability of lumbar primary Aδ afferent neurons, which may be induced along with suppressing IA currents via the decreased expression of Kv4.3. Thus, peripheral Aδ neuroplasticity may contribute to the chronic lower limb pain caused by SDV. Synapse, 2012. © 2011 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]

Published
2012
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8. Enhancement of glutamatergic transmission in the cingulate cortex in response to mild noxious stimuli under a neuropathic pain-like state.

Author

Niikura, Keiichi, Furuya, Masaharu, Narita, Michiko, Torigoe, Kazuhiro, Kobayashi, Yasuhisa, Takemura, Yoshinori, Yamazaki, Mitsuaki, Horiuchi, Hiroshi, Enomoto, Tatsuya, Iseki, Masako, Kinoshita, Hiroyuki, Tomiyasu, Shiro, Imai, Satoshi, Kuzumaki, Naoko, Suzuki, Tsutomu, and Narita, Minoru

Subjects
HEAT, NEURONS, CEREBRAL cortex, SCIATIC nerve, RATS
Abstract

The article discusses the study conducted to investigate the impact of mild noxious heat stimuli on the neuronal activity in the cingulate cortex (CG) of rats with sciatic nerve ligation. The mild noxious heat stimuli administered to rats seven days after sciatic nerve ligation produced flinching behaviors and resulted in an increase in glutamate release in the CG, and phosphorylated-NR1-positive cells, under a neuropathic pain.

Published
2011
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