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Introduction: The aim of our cross-sectional study is to determine whether there is a link between sex, skeletal class and mandibular asymmetry in orthodontic patients, with tooth length and asymmetry in tooth length on contralateral sides of the mandible. Methods: As the source for relevant data to answer this question, 3D cone-beam tomography (CBCT) images of a total of 95 future orthodontic patients were retrospectively selected from private practice records and were analyzed. The CBCT images were part of routine orthodontic diagnosis. Patients were divided into three groups (Class I, Class III with asymmetry and Class III without asymmetry) based on skeletal variables assessed on orthodontic cephalometric images and frontal photos of the face. Three null hypotheses were developed, and a series of statistical tests was performed in order to support or reject them. Results: We have established that there exists a sexual dimorphism in some of the teeth's lengths in our sample. Furthermore, we failed to find a link between mandibular asymmetry and asymmetry in tooth length. We have also found a link between skeletal class and tooth length differences in some of the analyzed measurements. Conclusions: Computational models used to design orthodontic appliances and to plan orthodontic treatment should be more individualized to consider a patient's sex and skeletal class. [ABSTRACT FROM AUTHOR]

Facial asymmetry is a feature that occurs to a greater or lesser extent in the general population. As its severity is usually slight, facial asymmetry may not be noticeable to the patient. However, there are cases when severe facial asymmetry not only affects the facial aesthetics by distorting facial proportions, but also contributes to problems related to the function of the stomatognathic system. The nodal signalling pathway appears to be of particular importance in the process of mandibular asymmetry, as it affects not only structures formed from the first pharyngeal arch, but also other organs, such as the heart and lungs. Following the evaluation of the available literature, the inheritance of mandibular asymmetry is a very complex and multifactorial process, and the genes whose altered expression appears to be a more important potential aetiological factor for asymmetry include PITX2, ACTN3, ENPP1 and ESR1. This systematic review attempts to systematise the available literature concerning the impact of signalling pathway disruption, including the disruption of the nodal signalling pathway, on the development of mandibular asymmetry. [ABSTRACT FROM AUTHOR]

Orthodontic treatment carries the risk of major complications such as enamel demineralization, tooth decay, gingivitis, and periodontal damage. A large number of elements of fixed orthodontic appliance results in the creation of additional plaque retention sites which increase the risk of biofilm creation. Modification of the surface of orthodontic elements may prevent the formation of bacterial biofilm. In this paper, surface modification of stainless steel orthodontic wires with TiO2: Ag was carried out by the sol-gel thin film dip-coating method. To obtain the anatase crystal structure, substrates were calcined for 2 h at 500 °C. The properties of the obtained coatings were investigated using scanning electron microscopy, X-ray diffraction, and electrochemical tests. Corrosion studies were performed in a Ringer's solution, which simulated physiological solution. SEM and XRD analyses of the coated surface confirmed the presence of Ag nanoparticles which may have antimicrobial potential. [ABSTRACT FROM AUTHOR]