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Background: Cryosurgery for prostate cancer is the ablation of the cancer by inducing a lethal freezing temperature (−40°C) to kill the cancer cells. This is now one of the optional curative treatments for localized prostate cancer patients. Methods: A third generation cryotherapy machine was used. An ultrathin 17 Fr cryoneedle was used to puncture the prostate gland transperineally under real-time transrectal ultrasound guidance. Cryogen gas, using argon, was used for active freezing and helium gas was used for active thawing. Thermoprobes were used to ensure the lethal temperature was reached. A urethral warmer device was necessary to reduce urethral damage. Foley catheterization was necessary for 2–3 days postoperatively. Results: Postoperative prostate specific antigen (PSA) level was monitored 3 monthly. Biochemical success (PSA < 0.4) can be achieved in most cases. Conclusion: This new cryoablation of prostate cancer can provide a minimally invasive option for localized prostate cancer patients. [ABSTRACT FROM AUTHOR]