1. Combined treatment of fourth ventricle ependymomas: report of 26 cases.
- Author
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Spagnoli D, Tomei G, Ceccarelli G, Grimoldi N, Lanterna A, Bello L, Sinisi MM, De Santis A, and Villani RM
- Subjects
- Adolescent, Adult, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Child, Child, Preschool, Combined Modality Therapy, Cranial Fossa, Posterior radiation effects, Cranial Fossa, Posterior surgery, Female, Follow-Up Studies, Fourth Ventricle radiation effects, Humans, Infant, Male, Middle Aged, Radiotherapy Dosage, Retrospective Studies, Survival Rate, Treatment Outcome, Brain Neoplasms mortality, Brain Neoplasms pathology, Brain Neoplasms therapy, Ependymoma mortality, Ependymoma pathology, Ependymoma therapy, Fourth Ventricle surgery
- Abstract
Background: This study investigated the relevance of prognostic factors and the impact of histological features in posterior fossa ependymoma., Methods: The charts of 26 patients (aged 1-59 years, mean 20.6 years; 11 adults) with posterior fossa ependymoma operated on between January 1983 and December 1994 were reviewed and patients followed up (mean: 93 months)., Results: Gross total resection was performed in 18 patients (69%), subtotal in seven patients (27%), biopsy in one patient (4%). One patient (3.8%) developed respiratory complications and died. All patients underwent posterior fossa radiotherapy (5000 cGy) after surgery. Four children first received chemotherapy and then radiotherapy only when at least 3 years old. Eleven patients (42%) received radiotherapy and subsequently chemotherapy. The 5-year survival rate was 90% for adults and 40% for children (
- Published
- 2000
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