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BACKGROUND Outcomes in patients with brain metastases from gastrointestinal tract cancers are not well defined. In this study we used precise, single-session, focal tumor irradiation (radiosurgery) in patients with brain metastases and evaluated the results. METHODS Thirty-nine patients had brain metastases from gastrointestinal tract cancer and were treated with radiosurgery. Thirty-two also had whole brain radiotherapy. Primary lesions included colorectal cancer (n = 25), esophageal cancer (n = 11), cholangiocarcinoma (n = 1), duodenal cancer (n = 1), and jejunal cancer (n = 1). Seventy-two tumors were treated. RESULTS The overall median survival was 9 months after diagnosis of metastatic brain disease and 5 months after radiosurgery. The 1-year survival rate after radiosurgery was 19%. The last imaging study of 49 tumors showed complete remission (CR) in 3 tumors (6.1%), partial remission (PR) in 27 tumors (55.1%), no change (NC) in 11 tumors (22.4%), and progression in 8 tumors (16.3%). The local tumor control rate (CR, PR, NC) was 84%. Two patients (5.1%) had a new or worsening neurologic deficit after radiosurgery. CONCLUSIONS Stereotactic radiosurgery provides reasonable local control of brain metastases from gastrointestinal tract cancer with few side effects. However, it should be used judiciously in patients with active extracranial cancers since the expected survival may be limited.

BACKGROUND Most metastatic skull lesions are asymptomatic, although they can cause severe disability due to compression of dural sinuses and cranial nerves. The authors present current cases of calvarial and skull base metastases. Clinical features are compared to those of primary skull tumors and tumor-like lesions. METHODS We retrospectively reviewed the charts and radiographic images of 38 patients who underwent surgery for a skull lesion at our department between 1991 and 2001. The literature on skull metastases was reviewed. RESULTS In 12 cases, histologic examination revealed skull metastases. Eleven patients were known to suffer from cancer at the time of presentation. However, in 5 cases metastatic lesions were the first evidence of disseminated disease. Radical resection was possible in 9 cases. Removal and reconstruction of the infiltrated dura mater was necessary in 5 patients, whereas reconstruction of the bone was required in 8 patients. In comparison to 18 cases with primary skull tumors, patients with skull metastases presented less frequently with a neurologic deficit (3/12 vs. 9/18), reported a shorter history of symptoms (median 2 months vs. 24 months), and were older (median 70 years vs. 51 years). CONCLUSION Patients presenting with skull metastases are often in an advanced stage of disease, although surgery can relieve symptoms quickly and effectively with low morbidity. In particular, patients with signs of dura infiltration and related neurologic deficit should be offered neurosurgical therapy.

A review of the literature reveals 20 reported cases of acute spontaneous subdural hematoma. We present an additional case with a tabulation of pertinent data. The prototype case is described, emphasizing the benign and insidious onset followed, invariably, by a deteriorating neurological status leading, almost always, to surgical evacuation. A high index of suspicion for this entity is of great importance, because a delay in diagnosis may lead to an increase in the morbidity and the mortality of this condition.

Decerebrate and/or decorticate posturing have not yet been described as possible features of the syndrome of inappropriate secretion of antidiuretic hormone. Cerebral edema and loss of brain electrolytes are contributing factors resulting in altered excitability of the neural membrane. We describe a patient who, on the eighth day after a head injury, presented with decerebrate posturing, which coincided with the development of the syndrome of inappropriate secretion of antidiuretic hormone, and which rapidly reversed with the correction of the hyponatremia. We believe that the syndrome of inappropriate secretion of antidiuretic hormone should be included in the differential diagnosis of abnormal posturing in the head-injured patient.