1. Epidemiology and Drug Resistance Analysis of Mixed Infection in Orthopedic Surgical Sites
- Author
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Bin Zhang, Runsheng Guo, Wenye Yao, Niya Hu, Min Dai, Banglin Xie, Xiaowei Yang, Qi Lai, and Lijun Wan
- Subjects
Microbiology (medical) ,Drug ,Male ,medicine.medical_specialty ,interaction between bacteria ,Microbiological culture ,media_common.quotation_subject ,Drug resistance ,Hospitals, University ,03 medical and health sciences ,0302 clinical medicine ,Antibiotic resistance ,Internal medicine ,Epidemiology ,Drug Resistance, Bacterial ,medicine ,Humans ,Surgical Wound Infection ,Orthopedic Procedures ,030212 general & internal medicine ,media_common ,Retrospective Studies ,0303 health sciences ,drug resistance ,030306 microbiology ,business.industry ,Orthopedic Surgical Procedure ,Original Articles ,Bacterial Infections ,mixed infection ,Infectious Diseases ,Mycoses ,Orthopedic surgery ,Surgery ,distribution of pathogenic bacteria ,Female ,orthopedic surgical procedures ,business ,Surgical incision - Abstract
Background: Infection, including mixed infection, is not uncommon in orthopedic surgical incision. This study aimed to investigate the epidemiology and drug resistance of mixed infections after orthopedic surgical procedures. Methods: We retrospectively analyzed 533 orthopedic surgical site infections (SSIs) in a university hospital from 2012 to 2017. Eighty-six patients (218 strains) with bacterial culture results showing more than one strain were screened to explore their epidemiology and drug resistance. Results: Of 218 bacterial strains, 2-7 bacterial infections were noted in each wound. Most infections were caused by two kinds of bacteria (65.1%). The number of infections decreased with increased number of strains. The combinations of pathogenic micro-organisms were all gram-negative, 55.81%; gram-positive and gram-negative, 30.23%; all gram-positive, 12.79%; and gram-positive and fungi, 1.16%. Their resistance is consistent with the bacterial resistance of 447 cases of single bacterial SSI during the same period. Hospitalization duration was longer (9.8-20.6 d). Conclusion: Our study shows no significant changes in epidemiology and drug resistance caused by mixed infections in the orthopedic surgical site because of coordination and competition among micro-organisms. These bacteria are difficult to control, leading to extended hospitalization. Antibiotic agents should be chosen strictly according to drug sensitivity, and ineffective antibiotic agents must be avoided.
- Published
- 2020