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Your search keyword '"Clavien, Pierre A."' showing total 26 results
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26 results on '"Clavien, Pierre A."'

1. Revival of associating liver partition and portal vein ligation for staged hepatectomy for perihilar cholangiocarcinoma: An international multicenter study with promising outcomes

Author

Balci, Deniz, Nadalin, Silvio, Mehrabi, Arianeb, Alikhanov, Ruslan, Fernandes, Eduardo S.M., Di Benedetto, Fabrizio, Hernandez-Alejandro, Roberto, Björnsson, Bergthor, Efanov, Mikhail, Capobianco, Ivan, Clavien, Pierre-Alain, Kirimker, Elvan Onur, and Petrowsky, Henrik

Published
2023
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2. Vascular injury during cholecystectomy: A multicenter critical analysis behind the drama

Author

Lopez-Lopez, Victor, Kuemmerli, Christoph, Cutillas, Jose, Maupoey, Javier, López-Andujar, Rafael, Ramos, Emilio, Mils, Kristel, Valdivieso, Andres, Valero, Arkaitz Perfecto, Martinez, Pedro Antonio, Paterna, Sandra, Serrablo, Alejando, Reese, Tim, Oldhafer, Karl, Brusadin, Roberto, Conesa, Asunción López, Valladares, Luis Díez, Loinaz, Carmelo, Garcés-Albir, Marina, Sabater, Luis, Mocchegiani, Federico, Vivarelli, Marco, Pérez, Sergio Annese, Flores, Benito, Lucena, Jose Luis, Sánchez-Cabús, Santiago, Calero, Alicia, Minguillon, Antonio, Ramia, Jose Manuel, Alcazar, Cándido, Aguilo, Javier, Ruiperez-Valiente, Jose A., Grochola, Lukasz Filip, Clavien, Pierre-Alain, Petrowsky, Henrik, and Robles-Campos, Ricardo

Published
2022
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3. Bile formation in long-term ex situ perfused livers

Author

Eshmuminov, Dilmurodjon, Schuler, Martin J., Becker, Dustin, Bautista Borrego, Lucia, Mueller, Matteo, Hagedorn, Catherine, Häusler, Stephanie, Steiger, Julia, Tibbitt, Mark W., Dutkowski, Philipp, Rudolf von Rohr, Philipp, Stieger, Bruno, Hefti, Max, and Clavien, Pierre-Alain

Published
2021
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9. Survival after associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) for advanced colorectal liver metastases: A case-matched comparison with palliative systemic therapy

Author

Olthof, Pim B., Huiskens, Joost, Wicherts, Dennis A., Huespe, Pablo E., Ardiles, Victoria, Robles-Campos, Ricardo, Adam, René, Linecker, Michael, Clavien, Pierre-Alain, Koopman, Miriam, Verhoef, Cornelis, Punt, Cornelis J.A., van Gulik, Thomas M., and de Santibanes, Eduardo

Published
2017
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21. Reply

Author

Selzner, Markus and Clavien, Pierre-Alain

Published
2001

26. Bile formation in long-term ex situ perfused livers

Author

Philipp Rudolf von Rohr, Dilmurodjon Eshmuminov, Stephanie Häusler, Max Hefti, Matteo Mueller, Dustin Becker, Bruno Stieger, Pierre-Alain Clavien, Julia Steiger, Lucia Bautista Borrego, Martin J. Schuler, Philipp Dutkowski, Catherine Hagedorn, Mark W. Tibbitt, University of Zurich, and Clavien, Pierre-Alain

Subjects
Swine, Biopsy, medicine.medical_treatment, 610 Medicine & health, Stimulation, In Vitro Techniques, 030230 surgery, Pharmacology, Liver transplantation, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Bolus (medicine), Liver Function Tests, Animals, Bile, Humans, Medicine, 10217 Clinic for Visceral and Transplantation Surgery, medicine.diagnostic_test, business.industry, Graft Survival, Taurocholic acid, Ursodeoxycholic acid, 2746 Surgery, Liver Transplantation, Perfusion, Liver, chemistry, 10199 Clinic for Clinical Pharmacology and Toxicology, 030220 oncology & carcinogenesis, Models, Animal, Female, Surgery, Liver function, business, Liver function tests, Biomarkers, medicine.drug
Abstract

Long-term ex situ liver perfusion may rescue injured grafts. Little is known about bile flow during long-term perfusion. We report the development of a bile stimulation protocol and motivate bile flow as a viability marker during long-term ex situ liver perfusion.Porcine and human livers were perfused with blood at close to physiologic conditions. Our perfusion protocol was established during phase 1 with porcine livers (n = 23). Taurocholic acid was applied to stimulate bile flow. The addition of piperacillin-tazobactam (tazobac) and methylprednisolone was modified from daily bolus to controlled continuous application. We adapted the protocol to human livers (n = 12) during phase 2. Taurocholic acid was replaced with medical grade ursodeoxycholic acid.Phase 2: Despite administering taurocholic acid, bile flow declined from 29.3 ± 6.5 to 9.3 ± 1.4 mL/h (P.001). Shortly after bolus of tazobac/methylprednisolone, bile flow recovered to 39.0 ± 9.7 mL/h with a decrease of solid bile components. This implied bile salt independent bile flow stimulation by tazobac/methylprednisolone. Phase 2: Ursodeoxycholic acid was shown to stimulate bile flow ex situ in human livers. Eight livers were perfused successfully for 1 week with continuous bile flow. The other 4 livers demonstrated progressive cell death, of which only 1 exhibited bile flow.A lack of bile flow stimulation leads to a decline in bile flow and is not necessarily a sign of deterioration in liver function. Proper administration of stimulators can induce constant bile flow during ex situ liver perfusion for up to 1 week. Medical grade ursodeoxycholic acid is a suitable replacement for nonmedical grade taurocholic acid. The presence of bile flow alone is not sufficient to assess liver viability.

Published
2021

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