10 results
Search Results
2. Social and sexual health of thyroid cancer survivors 2 and 5 years after diagnosis: the VICAN survey.
- Author
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Creff, Gwenaelle, Jegoux, Franck, Bendiane, Marc Karim, Babin, Emmanuel, and Licaj, Idlir
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CANCER survivors ,SEXUAL health ,LUST ,THYROID cancer ,TELEPHONE interviewing ,DIAGNOSIS - Abstract
Purpose: Thyroid cancer (TC) incidence is increasing. With its good prognosis and the young population concerned, the number of survivors is rising. However, their quality of life appears worse than expected. This study aims to assess the social and sexual health (SSH) of TC survivors and associated factors after a 2- and 5-year follow-up. Methods: This study belongs to the National VICAN Survey implemented in France among TC patients diagnosed between January and June 2010. Data were collected via phone interviews, medical surveys, and from medico-administrative register in 2012 and 2015. We used multivariable logistic regressions to qualify TC impact on SSH. Results: Across 146 patients, 121 were women, 50.7% were less than 42 years old, 77.5% were diagnosed at an early-stage, and 97.6% underwent thyroidectomy. At 2 years, 60.0% experienced social life discomfort because of cancer, 40.6% reported a decreased sexual desire, 37.4% fewer intercourse, 31.9% felt dissatisfied with this frequency, 30% reported difficulties achieving orgasm, and 15.2% considered that cancer had a negative influence for procreation. No significant difference was observed at 5 years. SSH was never discussed with medical professionals for 96.7% patients, as it was not proposed as a topic of concern (79.1%). In multivariable analysis, depression, embarrassment regarding their physical appearance since treatment, and reduced gestures of affection remained associated with decreased sexual desire. Conclusion: This study highlights that TC is associated with an alteration of SSH which remains even at 5 years post-diagnosis. SSH should be discussed during diagnosis and considered during follow-up. [ABSTRACT FROM AUTHOR]
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- 2022
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3. Feasibility of a video-based cognitive behavioral therapy for insomnia in French adult cancer outpatients: results from the Sleep-4-All-1 study.
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Boinon, Diane, Charles, Cécile, Fasse, Léonor, Journiac, Jonathan, Pallubicki, Gloria, Lamore, Kristopher, Ninot, Grégory, Guerdoux-Ninot, Estelle, Gouy, Sébastien, Albiges, Laurence, Delaloge, Suzette, Malka, David, Planchard, David, Savard, Josée, and Dauchy, Sarah
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COGNITIVE therapy ,INSOMNIA ,CANCER patients ,OUTPATIENTS ,SLEEP hygiene ,SYMPTOMS - Abstract
Background: Insomnia affects up to 63% of patients with cancer. Cognitive behavioral therapy for insomnia (CBT-I) is considered to be the non-pharmacological gold standard treatment, but it remains underutilized in France. Self-administered interventions offer new ways to overcome some of the barriers that restrict access to efficacious supportive care. Objective: To assess the feasibility, among French adult cancer outpatients, of a validated Quebec video-based, self-administered, cognitive behavioral therapy for insomnia (VCBT-I). Methods: A pre-post design with quantitative measures (Insomnia Severity Index, Edmonton Symptom Assessment System, Treatment Perception Questionnaire) and qualitative measures (semi-structured interviews) was used. Results: One hundred and seventy-three cancer outpatients were self-screened for insomnia, and 57% (n=99) reported significant symptoms. Among them, 80% (n=79) agreed to participate in the VCBT-I. The download rate of the VCBT-I was 78% (n=62/79). Several technical and contextual barriers to the delivery and the applicability of the VCBT-I emerged. However, participants reported a high level of satisfaction, and some valuable benefits at post-immediate intervention (increased knowledge about sleep, better quality of sleep, and higher acceptance of the burden of insomnia), regardless of whether or not they still had insomnia. Discussion: This study confirms that there is a demand for a VCBT-I, which was perceived as appropriate by a sample of French cancer outpatients with insomnia, but it also highlights some limitations in terms of implementation and practicality. Remote professional support appears to be a core need in order to address these issues and personalize the guidance process. [ABSTRACT FROM AUTHOR]
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- 2021
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4. The use of complementary medicine in palliative care in France: an observational cross-sectional study.
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Filbet, Marilene, Schloss, Janet, Maret, Jean-Baptiste, Diezel, Helene, Palmgren, Per J., and Steel, Amie
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PALLIATIVE treatment ,MEDICAL personnel ,ALTERNATIVE medicine ,HOMEOPATHIC physicians ,OSTEOPATHIC physicians ,CROSS-sectional method ,SCIENTIFIC observation - Abstract
Purpose: Palliative care for cancer deals with physical, psychosocial, and spiritual issues faced by cancer patients, their families, communities, and healthcare providers. Research on complementary medicine (CM) use in France is limited despite high rates of reported CM use in other countries including by palliative patients. This study describes the use of CM by individuals receiving palliative care in Lyon, France. Design: This study employed an observational cross-sectional survey design. Setting/participants: The study was conducted in three palliative care centers in Lyon, France; two tertiary hospitals and one palliative care unit (3 sites). Inpatients and outpatients visiting the palliative care clinic with a primary diagnosis of cancer at each study site were invited to participate. Results: Of 138 eligible patients, 100 completed the survey (RR 72.4%). The majority (90.7%) reported using CM in the previous 6 months or since their primary cancer diagnosis. Participant CM use was either the same (20.7%) or increased since their primary cancer diagnosis (33.7%). Average out-of-pocket expenses associated with CM use in the previous 6 months or since diagnosis were €157.40 (SD €330.15). The most common CM health professional visited was an aromatherapist (72.7%), a Coupeurs de feu (38.6%), osteopath (28.6%) and naturopath (15.3%). The most common CM used were aromatherapy oils (33.7%), homeopathy (30.0%), and vitamins (29.4%). Conclusion: This second survey on CM use in France; is the first conducted in palliative care centers. Results show people with cancer in Lyon, France, have a very high prevalence of CM utilization. [ABSTRACT FROM AUTHOR]
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- 2020
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5. The humanistic burden associated with caring for patients with advanced non-small cell lung cancer (NSCLC) in three European countries-a real-world survey of caregivers.
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Wood, R., Taylor-Stokes, G., and Lees, M.
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NON-small-cell lung carcinoma ,BURDEN of care ,CAREGIVERS ,FULL-time employment ,LUNG cancer treatment ,TREATMENT of lung tumors ,PSYCHOLOGY of caregivers ,COMPARATIVE studies ,ECONOMIC aspects of diseases ,EMPLOYMENT ,LUNG cancer ,LUNG tumors ,RESEARCH methodology ,MEDICAL care ,MEDICAL cooperation ,PATIENTS ,QUALITY of life ,RESEARCH ,EVALUATION research ,CROSS-sectional method ,PSYCHOLOGY - Abstract
Purpose: This study evaluated the humanistic burden on caregivers of patients with advanced non-small cell lung cancer (aNSCLC) as the disease progresses.Methods: Data were drawn from a cross-sectional study of patients with aNSCLC and their caregivers conducted in France, Germany, and Italy between 2015 and 2016. Data were collected by medical chart review and patient and caregiver questionnaires. The EuroQol five-dimension three-level (EQ-5D-3L) was used to evaluate patient and caregiver health status. Caregivers also completed the Work Productivity and Activity Impairment (WPAI) questionnaire and Zarit Burden Interview (ZBI).Results: The population for the analysis consisted of 427 caregivers (mean age 53.5 years; 72.6% female; 54.9% spouse; 36.2% in full-time employment) and 427 matched patients (mean age 66.2 years; 68.6% male). Most (69.5%) patients were receiving first-line therapy for advanced disease. Patients' caregivers provided a mean of 29.5 h of support per week. Significant differences in EQ-5D-3L scores were observed between caregivers of patients receiving first and later lines of therapy in France (0.87 vs. 0.78; p = 0.0055). Among employed caregivers, overall work impairment was considerable and ranged from 21.1% in Germany to 30.4% in France and 29.7% in Italy. Caregivers of patients receiving later lines of therapy in France rated their own health status as significantly worse than did those caring for patients receiving first-line therapy (82.7 vs. 72.9; p = 0.0039).Conclusions: Informal caregivers provided the majority of support for patients with advanced NSCLC and their caregiving activities impose a significant humanistic burden. [ABSTRACT FROM AUTHOR]- Published
- 2019
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6. Sexual health and needs for sexology care in digestive cancer patients undergoing chemotherapy: a 4-month cross-sectional study in a French University Hospital.
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Almont, Thierry, Couteau, Corinne, Etienne, Hélène, Bondil, Pierre, Guimbaud, Rosine, Schover, Leslie, and Huyghe, Éric
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CANCER patients ,STOMACH cancer treatment ,CHEMOTHERAPY complications ,QUALITY of life ,PANCREATIC cancer treatment ,HUMAN sexuality ,MENTAL health ,SEXOLOGY ,ACADEMIC medical centers ,CROSS-sectional method ,GASTROINTESTINAL tumors ,RESEARCH funding ,QUESTIONNAIRES - Abstract
Purpose: To assess sexual health and needs for sexology care of cancer patients during chemotherapy.Methods: We performed a 4-month cross-sectional study in cancer patients treated by chemotherapy in the digestive cancer department of a regional university hospital. Patients were asked to fill out a self-administered questionnaire about their sexual health, Sexual Quality of Life Questionnaire for Male (SQoL-M) or Female (SQoL-F), and their needs for sexology care.Results: The study sample was composed of 47 men and 31 women. Tumor locations were 36 colorectal (46%), 23 pancreatic (30%), and 19 other digestive cancers (24%). SQoL scores were lower in women (p < .001), in pancreatic and colorectal tumors (p = .041 and p = .033, respectively) compared to other digestive cancers, and in less-educated patients (p = .023). During chemotherapy, 40% of sexually active patients had less frequent sexual intercourse than before diagnosis, and 33% had completely stopped sexual activity. Sexuality care was desired by 44% of respondents. Among them, 83% favored a consultation with a medical sexologist and 63% with a psycho-sexologist, 54% wanted couple therapy, and 31% considered support groups. Patients with colorectal cancer had more frequent sexual intercourse without penetration at the time of survey (p = .036) and more often wanted couple therapy than patients with pancreatic cancer (p = .048).Conclusions: This study is the first determination of sexual health and sexual quality of life in digestive cancers. Targets for interventions during chemotherapy for digestive cancers include populations with lower sexual quality of life: women, pancreatic sites, patients with sexual troubles during chemotherapy, and less-educated patients. [ABSTRACT FROM AUTHOR]- Published
- 2018
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7. Dalteparin or vitamin K antagonists to prevent recurrent venous thromboembolism in cancer patients: a patient-level economic analysis for France and Austria.
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Dranitsaris, George, Shane, Lesley, Galanaud, Jean-Philippe, Stemer, Gunar, Debourdeau, Philippe, Woodruff, Seth, and Shane, Lesley G
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THROMBOEMBOLISM ,DALTEPARIN (Drug) ,CANCER patients ,VITAMIN K ,HEPARIN ,PHYSIOLOGY ,PATIENTS ,THERAPEUTICS ,VITAMIN therapy ,ANTICOAGULANTS ,QUALITY of life ,MENTAL health ,THROMBOEMBOLISM prevention ,COST effectiveness ,TUMORS ,VEINS ,DISEASE relapse ,CHEMICAL inhibitors ,ENOXAPARIN ,DISEASE complications ,PHARMACODYNAMICS - Abstract
Background: International guidelines recommend extended duration secondary prophylaxis in cancer patients who develop primary venous thromboembolism (VTE). Agent selection is guided in part by one large randomized trial (i.e., CLOT; Lee et al., N Engl J Med 349:146-53, 2003) which demonstrated that dalteparin reduced the relative risk of recurrence by 52% compared with oral vitamin K antagonists (VKA; HR = 0.48, 95% CI, 0.30 to 0.77). In a subgroup analysis from that same trial, patients with renal impairment also derived benefit with dalteparin (VTE rates = 3% vs. 17%; p = 0.011). To measure the economic value of secondary VTE prophylaxis with dalteparin, a patient-level pharmacoeconomic analysis was conducted from the Austrian and French healthcare system perspectives.Methods: Chapter 1 Healthcare resource use collected during the CLOT trial was extracted and converted into direct cost estimates. Incremental cost differences between the dalteparin and VKA groups were then combined with health state utilities to measure the cost per quality-adjusted life year (QALY) gained.Results: The dalteparin group had significantly higher costs than the VKA group in both countries (Austria: dalteparin = €2687 vs. VKA = €2012; France: dalteparin = €2053 vs. VKA = €1352: p < 0.001). However, when the incremental costs were combined with the utility gain, dalteparin had a cost of €6600 and €4900 per QALY gained in Austria and France, respectively. The analyses in patients with renal impairment suggested an even better economic profile, with the cost per QALY gained being less than €4000 in both countries.Conclusions: Secondary prophylaxis with dalteparin is a cost-effective alternative to VKA for the prevention of recurrent VTE in patients with cancer. [ABSTRACT FROM AUTHOR]- Published
- 2017
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8. Use of iron sucrose and red blood cell transfusions in anaemic cancer patients in France (OncoFer study).
- Author
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Luporsi, Elisabeth, Toledano, Alain, Spaeth, Dominique, Scotté, Florian, Espié, Marc, Perot, Stéphanie, Duvillié, Ladan, Pithois Merli, Isabelle, Bugat, Roland, Scotté, Florian, Espié, Marc, Perot, Stéphanie, and Duvillié, Ladan
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ANEMIA treatment ,RED blood cell transfusion ,SUCROSE ,CANCER patients ,FERRITIN ,THERAPEUTIC use of iron ,ADVERSE health care events ,THERAPEUTICS ,ANEMIA ,COMPARATIVE studies ,HEMOGLOBINS ,IRON compounds ,RESEARCH methodology ,MEDICAL cooperation ,RESEARCH ,SWEETENERS ,TUMORS ,EVALUATION research ,RETROSPECTIVE studies ,HEMATOLOGIC malignancies - Abstract
Purpose: This report describes the results of an observational, retrospective cohort study, evaluating the use of iron sucrose (IS) and red blood cell (RBC) transfusions in patients with cancer in routine clinical practice in France. A parallel investigated cohort treated with ferric carboxymaltose (FCM) has been reported earlier.Methods: Data of patients with a solid tumour or haematological malignancy who have received IS or an RBC transfusion during 2010 from 3 months prior (M-3) to 3 months post first treatment (M+3) were analysed.Results: Data from 46 patients who had received IS (400 mg median total iron dose) and 357 patients who had received RBC transfusions as first treatment (baseline) were included. Median haemoglobin levels improved from 9.9 g/dL (interquartile range 9.2; 11.0 g/dL) at baseline to 12.4 g/dL (11.4; 13.1 g/dL) at M+3 in IS-treated patients and from 8.2 g/dL (7.8; 8.8 g/dL) at baseline to 10.1 g/dL (8.8; 11.1 g/dL) in transfused patients. An erythropoiesis-stimulating agent was given to 54.3 and 28.9% of patients in the IS and the RBC transfusion groups, respectively, resulting in slightly better mean haemoglobin increase in both groups (2.4 vs 1.5 g/dL and 2.0 vs 1.6 g/dL, respectively). No severe nor serious adverse reaction and no hypersensitivity reactions were reported.Conclusion: Both IS and RBC transfusions effectively increased Hb levels in patients with cancer. IS was safe and well tolerated in this population. Considering prior reported results with FCM, using FCM may reduce ESA dose requirements and the required number of infusions. [ABSTRACT FROM AUTHOR]- Published
- 2017
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9. Clinical use of ferric carboxymaltose in patients with solid tumours or haematological malignancies in France.
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Toledano, Alain, Luporsi, Elisabeth, Morere, Jean, Scotté, Florian, Laribi, Kamel, Barrière, Jérôme, Huot-Marchand, Philippe, Duvillié, Ladan, Concas, Victor, Bugat, Roland, Morere, Jean François, Scotté, Florian, Barrière, Jérôme, Duvillié, Ladan, and Concas, Victor Hugo
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HEMATOLOGIC malignancies ,IRON deficiency anemia treatment ,CHEMOTHERAPY complications ,CANCER patients ,ALLERGY treatment ,THERAPEUTICS ,IRON compounds ,HEMATOPOIETIC agents ,ANTINEOPLASTIC agents ,CLINICAL trials ,HEMOGLOBINS ,IRON ,IRON deficiency anemia ,LONGITUDINAL method ,SWEETENERS - Abstract
Purpose: This study collected data on the use of ferric carboxymaltose (FCM) in a cancer patient population in France to evaluate the feasibility and the conditions of use of FCM in routine clinical practice beyond the limiting criteria of clinical trials.Methods: This observational, prospective study of patients with a solid tumour or a haematological malignancy who have received treatment with FCM after 01 July 2011 evaluated data about the circumstances of iron administration, concomitant medication and laboratory tests in the period from 3 months prior to the first FCM administration (baseline) until 3 months post-baseline.Results: Data from 367 FCM-treated patients were analysed. FCM was mainly given as a single dose at baseline (69.2%) and without additional erythropoiesis-stimulating agent (ESA, 64.3%). The median total iron dose was 1000 mg per patient. Median haemoglobin (Hb) levels of FCM-treated patients improved from 10.3 g/dL (interquartile range 9.5, 11.1 g/dL) at baseline to 11.8 g/dL (11.1, 13.0 g/dL) until the end of the 3-month observational period. Patients treated with FCM alone or additional ESA achieved similar median Hb increase (1.3 [0.4, 2.1] g/dL and 1.4 [0.4, 2.5] g/dL, respectively). Patients with baseline Hb up to 11.0 g/dL and serum ferritin up to 500 ng/mL and beyond achieved stable median Hb levels ≥11.0 g/dL without signs of iron overload. No severe or serious adverse reaction and no hypersensitivity reactions were reported.Conclusions: The results of this observational study confirm the effectiveness and tolerability of FCM when given in clinical routine practice alone or in combination with an ESA. [ABSTRACT FROM AUTHOR]- Published
- 2016
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10. Communication with terminal cancer patients in palliative care: are there differences between nurses and physicians?
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Levorato, Stiefel, Mazzocato, Bruera, Levorato, A, Stiefel, F, Mazzocato, C, and Bruera, E
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TERMINAL care ,TERMINAL care statistics ,ATTITUDE (Psychology) ,CHI-squared test ,COMMUNICATION ,DECISION making ,DO-not-resuscitate orders ,INTERPROFESSIONAL relations ,MEDICAL personnel ,NONPARAMETRIC statistics ,NURSES ,PSYCHOLOGY of nurses ,PALLIATIVE treatment ,PHYSICIANS ,PSYCHOLOGY of physicians ,QUESTIONNAIRES ,PSYCHOLOGY of the terminally ill ,STANDARDS - Abstract
The aim of this study was to find whether there were interprofessional differences in specific elements of communication with terminal cancer patients and decision-making processes that concern such patients. Given that interdisciplinary team work is one of the basic values in palliative care, if there are conflicting views between professions on such important issues it is most important to know about these and to understand them. A questionnaire utilized in an earlier survey of palliative care physicians and addressing their attitudes to and beliefs about specific elements of communication and decision making was sent to a sample of palliative care nurses working in the same regions, i.e. the French-speaking parts of Switzerland, Belgium and France. After a second mailing (reminder), 135 of the 163 questionnaires (83%) were returned. There was general agreement between nurses and physicians on questions dealing with perceptions of patients' knowledge of their diagnosis and stage of disease, patients' need for information, "do not resuscitate" orders and ethical principles in decision-making processes. Statistically significant, but small, differences between professional groups were only observed for a minority of the questions. Interprofessional differences in specific elements of communication with terminal cancer patients and decision-making processes affecting these patients were not so marked that they could be called "conflicting interprofessional views." [ABSTRACT FROM AUTHOR]
- Published
- 2001
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